Reviewed a paper and signed off on the revision; now seeing re-reviews from other authors that are as long as the original list of concerns. I'm not sure when multiple rounds of review became normalized behavior, but it really needs to get unnormalized. IT'S JUST A PAPER.

Wow

Amazing atmosphere at the Emirates last night! Gotta give props to Lens section for carrying on despite the 6-0 score #ARSENAL #gooner #ucl #ArsvsLens #emirates

A fun project, check out our work!

/More retrons Speaking of genome engineering tools hiding in plain sight, let's turn our attention to retrons. Like CRISPR, retrons are a crazy byproduct of molecular warfare between bacteria and viruses:

So excited to share one of the final works from my PhD in Seth Shipman’s lab with Asim Khan and oso, where we used high-throughput libraries and machine learning to create design rules for retron gene editors: biorxiv.org/content/10.110…

Great way to kick off Premier League season

Continuous multiplexed phage genome editing using recombitrons go.nature.com/3yUNYTi

An experimental census of retrons, now published in Nature Biotechnology. We synthesized more than a hundred new retrons and put them through their paces, improved recombineering rates and precise editing in human cells up to 40%. nature.com/articles/s4158…

Here's the SharedIt link for free access to the paper: rdcu.be/dUbL7. Great job on this one Asim Khan Matías Rojas Montero Alex González-Delgado oso Rebecca Fang kate crawford, and institutional support Gladstone Institutes UC San Francisco UCSF Bioengineering & Therapeutic Sciences

Gladstone scientists undertake a major effort to examine the diversity of retrons, bacterial defense systems that can be leveraged for precise gene editing. Seth Shipman Asim Khan Matías Rojas Montero Alex González-Delgado Nature Biotechnology UC San Francisco UCSF Bioengineering & Therapeutic Sciences Chan Zuckerberg Biohub Network bit.ly/3XIMoxb

🚨 NEW PUBLICATION 🚨 "An experimental census of retrons for DNA production and genome editing" Seth Shipman Asim Khan Matías Rojas Montero Alex González-Delgado Nature Biotechnology UC San Francisco UCSF Bioengineering & Therapeutic Sciences Chan Zuckerberg Biohub Network nature.com/articles/s4158…

🚨New Pub: High throughput variant libraries and machine learning yield design rules for retron gene editors, now out in Nucleic Acids Res. This is a great one, and the last bit of kate crawford's PhD, who is off to David Bakar's Lab for a postdoc. academic.oup.com/nar/advance-ar…

Six new retrons just dropped! See how we isolated these cool bacterial immune systems from the wild in our latest preprint. From soil to sequence, we uncover the operons of these novel retrons and their phage defense properties. As a bonus, we repurpose them for genome editing 🧬

The sequel to our DRT2 story is here, and this one is once again full of surprises! This time around, the Sternberg Lab teamed up with the Wiedenheft Lab to study how DRT9 reverse transcriptases provide antiviral immunity. Here’s what we found: biorxiv.org/content/10.110…

1/10 Today in Science Magazine in collaboration with liugroup we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells. drive.google.com/file/d/1I-UbCR…

Thrilled to see our work on the cover of Nature Biotechnology

New Preprint!! Alex González-Delgado accomplished a major feat on this one: ported retron recombineering, which we love so much in E. coli, into 14 new bacterial species via a massive collaborative effort involving 9 labs! biorxiv.org/content/10.110…