PIEZO1-Mediated Mechanotransduction Regulates Collagen Synthesis on Nanostructured 2D and 3D Models of Fibrosis biorxiv.org/cgi/content/sh… #bioRxiv

Reminder of tomorrow (Friday 7/12) #clinicians roundtable with Rebecca Ryan on "Disorders of the #gutbrainaxis in #MECFS & #LongCovid " Please note time is different than usual: 9:00 am Eastern; 2:00 pm GMT; 3:00 pm CEST and 11:00 pm AEST Register at us06web.zoom.us/webinar/regist…

Lac-Phe is July’s “molecule of the month” in Trends in Endocrinology & Metabolism ! Congratulations to Shuke Xiao 肖舒克 Veronica Li Sarafan ChEM-H Stanford Pathology Stanford Knight Initiative for Brain Resilience Stanford Diabetes Research doi.org/10.1016/j.tem.…

1/ This is a thread on the latest study by Amy Proal, PhD Resia Pretorius et.al . The study (see attached) identified issues of complement activation, endothelium function and downregulation of the coagulation system :

Inhibition of Dopamine Conversion to Norepinephrine by Clostridia Metabolites Appears to be a Major Cause of Autism, Schizophrenia, and Other Neuropsychiatric Disorders #MECFS #LongCovid mosaicdx.com/resource/inhib…

1/ This is a major -and hopefully exciting- update on the use of #AI and #networkanalysis methods to research #MECFS. As new research was becoming available, it was sent to the #AI framework in order to identify most promising research targets. Here are the results :

We are excited to have supported this new study via our #LongCovid Research Consortium.  The project team are our incredible CUBoulder Neuroscience colleagues at the University of Colorado Boulder: polybio.org/multiple-hit-m…

🔥 Researchers have discovered a hidden talent of mast cells: they can capture and use another type of immune cell called neutrophils. This surprising discovery sheds new light on how our immune system works, particularly during allergic reactions. 1/

Today in @nature, we discover a new enzyme in mammalian taurine metabolism- and uncover a chemical connection between diet, genetics, and body weight. Congrats Wei Wei (魏伟) Sarafan ChEM-H Stanford Pathology Michael Fischbach Cholsoon Jang SvenssonLab Lingyin Li Lab nature.com/articles/s4158…

🚨Urgent🚨 I started a new GoFundMe a few days ago, I am now halfway towards meeting this goal. ~700/1500 I still need a lot of help to avoid being homeless for the 4th time with Severe ME/CFS. Every $/share counts <333 linktr.ee/hiimjakekthx gofund.me/ddc3f259

Hi, ER Doc here. If you witness someone pass out on to the ground, DO NOT RUSH THEM BACK UP TO A STANDING POSITION. This just decreases blood flow to their brain and can only make things worse. Please tell your friends about this.

We need to find as many examples as possible of people with ME who have had or are having home TPN (I/V feeding). Worldwide & especially the UK. Please will you/a family member/a carer contact us asap. Leave a reply & follow us so we can DM you. Please share this appeal.

Please contribute or share if you can! Autisdick ☭ 😷 🇵🇸🗣️ is one of the RemissionBiome MECFS/LongCovid Self-Experiment #Renegade50 participants who helps many people in this community.

The findings revealed a tractable brain-body mechanism linking psychological states to host defense. 12/12 cell.com/cell/fulltext/…

New! Online now: A nutrigeroscience approach: Dietary macronutrients and cellular senescence dlvr.it/TCFpMh

For context, a blood lactate of 4.5 is something I'd expect to see after running a solid 5k, at speed. Having this triggered by just doing paperwork is about the best example I can think of that something has gone terribly wrong in the basic biological machinery of life.

#CoagulationAndImmunity! Ryu, Katerina Akassoglou &co show nature that the #SARSCoV2 Spike binds & activates #fibrin, driving type I interferon signaling, macrophage activation, NK cell inhibition, & neuroinflammation, independently of infection! #LongCOVID nature.com/articles/s4158…

This shows for the first time, that mitochondria are able to recycle a localized injury, removing damaged cristae, and then function normally afterward. nature.com/articles/s4158…

I was going to present this Lightning Talk at the Stanford ME/CFS research meeting tomorrow, but due to a last minute shake-up, I won't be able to. So I'll present it here. Renegade Research Credit to Tess Falor, Ph.D. | @RemissionBiome for slide template. 1/n

Richard Lewis Nick Melia Renegade Research Tess Falor, Ph.D. | @RemissionBiome Oh yeah, we have lots of data on meds/supplements/interventions and have started looking at that now. Perhaps unsurprisingly: there is massive heterogeneity - a supplement that increases one person energy level by 30% can tank another person's by the same.