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Kaiser, Arpaia et al. Arpaia Lab Microbiology & Immunology at Columbia University show that, during #influenza virus infection, Treg cell–derived amphiregulin is sensed by EGFR+Collagen-14+ lung mesenchymal cells, promoting alveolar regeneration. bit.ly/3YAx58o #InfectiousDisease #MucosalImmunology

New publication from our lab out in Journal of Experimental Medicine! Kaiser and team show that, during #influenza virus infection, Treg cell–derived amphiregulin is sensed by EGFR+Collagen-14+ lung mesenchymal cells, promoting alveolar regeneration. rupress.org/jem/article/22…

Check out this exciting work from Microbiology & Immunology at Columbia University student Kate Kaiser in Arpaia Lab, recently published in Journal of Experimental Medicine!

Excited to share our work from my time at Microbiology & Immunology at Columbia University. In brief, dietary Tryptophan depletion rather specifically promotes RORγ+ Treg expansion in a microbiota dependent manner. Thanks to all involved 🙏❤️ cell.com/cell-reports/f…

Our March cover shows a lung section of a mouse infected with influenza virus (red) with Tregs (green) and stained for secreted extracellular matrix proteoglycan Agrin (white). From Kaiser et al Arpaia Lab (bit.ly/3KMFS2l). Read JEM’s March Issue: bit.ly/3IxZe8A

Excited to share our work from Dr Lucille Rankin and Arpaia Lab team in Microbiology & Immunology at Columbia University! In brief, dietary tryptophan deficiency promotes expansion of intestinal RORγ+ Tregs in a microbiota dependent manner.

Excited to see our work featured on the March cover of Journal of Experimental Medicine! Kaiser and Arpaia Lab team (Microbiology & Immunology at Columbia University) show Treg cell–derived amphiregulin is sensed by EGFR+Collagen-14+ lung mesenchymal cells in #influenza infection, promoting alveolar regeneration. tinyurl.com/2pb87dv7

This #InternationalWomensDay, the HICCC celebrates all of our doctors, patients, researchers, and staff, who have worked together to advance equitable cancer care for all. #EmbraceEquity #IWD23 #IWD Columbia Medicine NewYork-Presbyterian

Excited to share our work published today in Science Advances! Thomas Savage with Arpaia Lab and Tal Danino lab members engineer bacteria to intratumorally release chemokines that recruit T cells and DCs into tumors, activating anti-cancer immunity. tinyurl.com/ycxf3nss

Check out this beautiful new study on the mechanism of DNA double-strand break resection initiation from the lab of Microbiology & Immunology at Columbia University Professor Lorraine Symington, published this week in Molecular Cell!!! 🧬🧑‍🔧👇 doi.org/10.1016/j.molc…

New preprint! Engineered bacteria launch and control an oncolytic virus biorxiv.org/content/10.110… Exciting work from Zak Singer jpabon & lab engineering bacteria to deliver viral RNAs that launch viral spread. We also engineer the virus to depend on bacteria. Congrats all!

Excited to share our new preprint! We program probiotic bacteria to create a next generation anti-tumor vaccine that stimulates tumor neoantigen-specific immunity to control and eradicate solid tumors Columbia CMBS Columbia BME. biorxiv.org/content/10.110…

New paper today! Rosa, @cgurbatri and team engineer probiotics that make synthetic antigens to “paint” cancer cells and direct CAR-T cell activity. Enables targeting cells lacking TAAs. Bacterially produced chemokines also help CAR-Ts. w/Arpaia Lab doi.org/10.1126/scienc…

Congrats 🥳 Thomas Savage and team on a study published today in Immunity demonstrating Treg-derived amphiregulin promotes NASH-induced liver fibrosis and glucose intolerance! 🧑‍🔬🍔🍟 Columbia CMBS Microbiology & Immunology at Columbia University CU-DLDRC Columbia University VP&S MD-PHD Program tinyurl.com/2ptfr8wf

In this review, Loffredo, Savage, Ringham, & Arpaia Arpaia Lab Microbiology & Immunology at Columbia University examine interactions between Treg cells and tissue-resident non-immune cells—in the context of tissue repair, #fibrosis, and #cancer—and discuss areas for future exploration. hubs.la/Q02v9wxT0

New paper in collaboration w/The Arpaia Lab out in Nature today! Andrew Redenti, Jongwon Im and team engineer E. coli Nissle probiotic as cancer vaccines nature.com/articles/s4158… Columbia BME Herbert Irving Comprehensive Cancer Center. Congrats all!!

Congrats Fangda Li and team! Another great collab w/ Tal Danino's lab out today in Science Immunology! Programmable bacteria synergize with PD-1 blockade to overcome cancer cell–intrinsic immune resistance mechanisms. Microbiology & Immunology at Columbia University Columbia CMBS Herbert Irving Comprehensive Cancer Center science.org/doi/10.1126/sc…

Excited to share a preprint of our latest study in collaboration w/ Tal Danino's lab – synthetically engineered E. coli expressing CXCL13 synergizes with PD-1 blockade to amplify antitumor antibody responses and inhibit bladder cancer growth. Microbiology & Immunology at Columbia University biorxiv.org/content/10.110…

The Arpaia Lab is currently recruiting for a Staff Associate I position 🧑‍🔬. Please share the following job description and application link with anyone you believe would be interested. Thank you! apply.interfolio.com/167245