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The combination of nivolumab and ipilimumab in patients with metastatic colorectal cancer led to 24-month progression-free survival of 72%, as compared with 14% with chemotherapy. Read the full CheckMate 8HW trial results: nej.md/4eGp1tj #oncology

Exactly no one should be surprised!! AKI is managed by hospital medicine, very effectively

I did the ABIM MOC LKA today. There was a myeloma question. I’m quite certain this is the worst myeloma question I have ever seen in the history of myeloma questions. Everything was wrong. Everything. No one will learn from this. #EndMOC #MedTwitter

Viewpoint: Integrating engineering with medicine is fostering a new generation of "physicianeers" who are uniquely equipped to innovate and solve complex healthcare problems. ja.ma/4gCVMcR

The conventional way of classifying metastatic cancers according to their organ of origin is denying people access to drugs that could help them nature.com/articles/d4158…

Which revascularization strategy is best for patients with severe LV systolic dysfunction? Read the long-term mortality outcomes after CABG vs. PCI in severe ischaemic cardiomyopathy in #EHJ. doi.org/10.1093/eurhea… #revascularization #cardiotwitter European Society of Cardiology Journals European Society of Cardiology

Air pollution exposure and #cardiometabolic risk thelancet.com/journals/landi… #AirPollution #T2D

Redefining obesity. It is time. 📏BMI is NOT a direct measure of fat 📏BMI does NOT establish the distribution of fat 📏BMI cannot determine with excess fat is a health problem The Lancet Lancet Commision 📎 thelancet.com/commissions/cl…

A randomized trial of GPT-4 vs 92 physicians with or without this #AI LLM for performance on patient care tasks. AI improved physician performance, on par with AI alone (based on 5 clinical vignettes) nature.com/articles/s4159… Nature Medicine Adam Rodman Jonathan H Chen MD PhD

Treatment of gestational diabetes with metformin and additional glyburide, if needed, was not noninferior to insulin in preventing infants from being born large for gestational age. ja.ma/40SbjyS

Low-dose semaglutide reduced alcohol craving and consumption in adults with alcohol use disorder. ja.ma/3COtptq

I encourage every doctor to try out MedArena -- a Turing test of AI models on the tasks that YOU think are important!

It is important to be deliberate and comprehensive in the application of Generative AI to health care. All innovations in health care require balancing new approaches with appropriate guardrails. nejm.org/doi/full/10.10…

TAPER-V RCT🔥 14d vanco→taper (125 mg q12h ×7d,then q24h ×7d) vs placebo for initial CDI. Although not stat significant, vancomycin taper showed a trend toward reduced C. difficile recurrence by Day 56. Also reduced need for fidaxomicin, potentially lowering cost #ESCMIDGlobal

How well do FDA-cleared AI ECG tools do in the real world? The latest issue of NEJM AI has an important new study evaluating calibration of an FDA-cleared tool for identification of hypertrophic cardiomyopathy with disappointing real world performance but a pathway for

Huge update to our preprint today on the superhuman performance of reasoning models in medical diagnosis! TL;DR – they don't just surpass humans in meaningful benchmarks, but in actual medical care from unstructured clinical data: A 🧵⬇️: x.com/AdamRodmanMD/s…

BREAKING: Apple just proved AI "reasoning" models like Claude, DeepSeek-R1, and o3-mini don't actually reason at all. They just memorize patterns really well. Here's what Apple discovered: (hint: we're not as close to AGI as the hype suggests)

Improving the use of GDMT in practice is incredibly challenging Despite hope and prior claims that low-intensity electronic letter nudges to patients or clinicians are effective… No benefit found in this factorial RCT The NUDGE-CKD Trial | Circulation ahajournals.org/doi/abs/10.116…

Presented at #CCR25: A trial involving children with severe acute malnutrition and gastroenteritis showed no evidence of a difference in mortality at 96 hours between oral and intravenous rehydration strategies. Full GASTROSAM trial results: nej.md/3TjfSP7

There's a lot to be said on this newest preprint showing that reliance on LLMs in writing tasks leads to a 'consistent underperformance' in neural and behavioral levels with potential long-term consequences. Interestingly, I think this ties to similar but (early)