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A tremendous joint meeting Stanford CVI / PennCVI /Duke /WCM Cardiovascular Research Institute (CVRI) hosted by Stanford - inspiring keynote by NIH NHLBI director Gary Gibbons, amazing science all around, and lots of friends. Thank you Joseph C Wu, MD, PhD for hosting! Saptarsi Haldar Tom Cappola, MD Sharlene Day

CVI is accepting applications for AHA Summer Undergraduate Fellowships! Students who are underrepresented in medicine encouraged to apply. Application deadline is Feb 14, 2024. med.upenn.edu/cvi/american-h… #undergraduatefellowships #cardiologyresearch

Deadlines are approaching for Keystone Symposia #Cardiometabolic Diseases: #EthnicDiversity in #PrecisionMedicine, this February in Vancouver! See scholarship, abstract and discount reg dates: keysym.us/KSCardiometab24 #KSCardiometab24 #Cardiovascular

Cool:  Lauren has just been selected to serve as the intern on the American Society of Nephrology Policy and Advocacy committee for Jan-Dec 2024 !  First non-postdoc/fellow that they’ve accepted, apparently! Congratulations !! Lauren Elizabeth Lee American Society of Nephrology

High fat consumption & blood pressure elevation ft. Boa Kim, Wencao Zhao, Soon Tang, Michael Levin, @_AyonIbrahim, Yifan Yang, Ling Lai, Jian Li, The FitzGerald Lab, The Arany lab (PennCVI/ Penn IDOM) Emilia Roberts & Richard Assoian (PennSysPharmATT) tinyurl.com/35b3tfm5

Our latest review on peripartum cardiomyopathy #PPCM in NEJM this week -- review of mechanism, genetics, clinical management, epi and prognosis -- lots of unknowns, huge racial disparities. Hope you enjoy it! nejm.org/doi/full/10.10…

Review Article by Zoltan Arany, M.D., Ph.D. (The Arany lab): Peripartum Cardiomyopathy nej.md/48pUCx3 #Cardiology

Interested in TTN/DCM? Check out current edition of Journal of Clinical Investigation. 2 new reports: 1 by us w/ @Arany Lab and 1 from Miklos Kellermayer, plus commentary by Travis Hinson and Stuart Campbell. We know a lot more about TTN pathomechanisms! ...and we know what we don't know. 🧵1/4

New manuscript from our group studying DCM-TTNtvs and transcriptional modulators that reverse haploinsufficiency. ahajournals.org/doi/10.1161/CI…

14 key points from our recent review on peripartum cardiomyopathy #PPCM in NEJM , summarized in American College of Cardiology , thank you Melinda Davis. acc.org/Latest-in-Card…

A few days late:  Congratulations to Daniel Daniel Baker for winning the 2024 Phacilitate Young Scientist Award from Advanced Therapies Awards — including Glittering Gala dinner in Miami !

I am pleased to share a preprint ‘HIF2α-dependent inhibition of mitochondrial clustering of glutaminase suppresses clear cell renal cell carcinoma’. biorxiv.org/content/10.110…

CVI's Highlighted #PapersoftheWeek pubmed.ncbi.nlm.nih.gov/39041214/

Translating metabolic and cardiovascular research into effective treatments: What’s next? Some thoughts from several of us on the topic, in this issue of Cell: authors.elsevier.com/a/1jUX4L7PXqREY Juleen R. Zierath Jolanda van der Velden Ali Javaheri Anthony Rosenzweig, MD Deb Muoio

it's been a while since we posted... Here our recent review w/ Rong Tian, MD PhD on HUMAN cardiac metabolism in Cell Metabolism : deep dive going back 50+yrs - turned out to be >300 refs! Much is known, much MORE needs figured out... cell.com/cell-metabolis…

We think this one is groundbreaking: Do you wonder how #SGLT2 inhibitors protect from heart failure? We show that #empagliflozen directly activates PANK1, rate-limiting for CoA synthesis, in human hearts. You read it here first! biorxiv.org/content/10.110…

From our newest anniversary focus issue on #Metabolism! "Human cardiac metabolism" The Arany lab Penn Medicine & colleagues Read the review: cell.com/cell-metabolis… #50YearsofCell

Fantastic brief historical overview of mechanism behind #preeclampsia from brilliant friend Ananth Karumanchi in Journal of Clinical Investigation : jci.org/articles/view/…

New! Online now: Quantification of nutrient fluxes during acute exercise in mice dlvr.it/TFMr8Y

Reporting with pride: (1) our star Jessie Axsom is now Dr.! (2) her paper is out Cell Metabolism: unbelievably comprehensive quantification of fuel fluxes in #exercise mice - lots of surprises. #MoTrPAC: take note. w/Rabinowitz lab. Free link 50days: authors.elsevier.com/a/1jxL75WXUlWk…