#GUTImages from the paper by Yu et al entitled

'Spatial transcriptomics reveals a low extent of transcriptionally active hepatitis B virus integration in patients with HBsAg loss' via

bit.ly/4akU3Wz

Jing Ying #HepatitisB

#GUTAbstract by Yu et al on the paper

'Spatial transcriptomics reveals a low extent of transcriptionally active hepatitis B virus integration in patients with HBsAg loss' via bit.ly/3vGR0IY

Paper: bit.ly/4akU3Wz

Jing Ying #HBV #HepatitisB

Systematic discovery of neoepitope–HLA pairs for neoantigens shared among patients and tumor types - Genentech Adaptive Biotech go.nature.com/3M3zoMf

New #JITC article: Divergent tumor and immune cell reprogramming underlying immunotherapy response and immune-related adverse events in lung squamous cell carcinoma bit.ly/3S50JSc Jing Ying

16 databases of scRNAseq datasets. 👇 🧵 Reuse them! #singlecell #bioinformatics

Insights from a 30-year journey: function, regulation and therapeutic modulation of PD1 Nature Rev Immunol Honjo
nature.com/articles/s4157…

🥼 This Cancer Cell study by scientists at the NCI Center for Cancer Research (@theredmanMD, @gulleyj1, Dr. Pat Soon-Shiong & more) and collaborators illustrates the physiological and metabolic changes underlying #Tcell responses to neoadjuvant #immunotherapies .

📘: bit.ly/41PtqUR

Advancing CAR T cell therapy through the use of multidimensional omics data NatureRevClinOncol

nature.com/articles/s4157…

This study of 771 ipilimumab-nivolumab-treated melanoma patients shows worse PFS+OS for patients whose irAEs were treated with second-line immunosuppression compared to those managed with steroids only, irrespective of type of second-line immunosuppression ja.ma/3Ps48ax

Rational combinations of targeted cancer therapies: background, advances and challenges

*Highly* comprehensive review!! Critical reading to understand targeted therapy resistance mechanisms & how drug combinations can be identified to combat resistance.

nature.com/articles/s4157…

Two super exciting papers in Cell today looking at #fungi across multiple human #cancer types, thus expanding insights into the #tumor #microbiome - Straussman_Lab Knight Lab bit.ly/3RoLQGj and Iliev Lab Anders B. Dohlman, PhD bit.ly/3fodaHr #TCGA Cell

Now online in Cancer Discovery: Modulation of BCL-2 in Both T Cells and Tumor Cells to Enhance Chimeric Antigen Receptor T cell #Immunotherapy against Cancer Marco Ruella Ruella Lab Penn Medicine aacrjournals.org/cancerdiscover…

ICYMI: Single-cell multiomics dissection of basal and antigen-specific activation states of CD19-targeted CAR T cells bit.ly/3zhERb6 Rong Fan Zhiliang Carl June

Sex and cancer immunotherapy: Current understanding and challenges dlvr.it/STngYM

Thrilled to share our journey using single-cell multi-omics to do deep immunophenotyping in patients with ICI myocarditis

Circulation #CardioOnc Sean M Wu, MD PhD Single Cell Media

ahajournals.org/doi/10.1161/CI…

Sex-Biased ZRSR2 Mutations in Myeloid Malignancies Impair Plasmacytoid Dendritic Cell Activation and Apoptosis.
Now out online including this cool 'cover art' by Cancer Discovery ! cancerdiscovery.aacrjournals.org/content/early/…