Another important study from j mandula and Paulo Rodriguez Moffitt Research re: Notch signaling in lung cancer. Inhibition of Jag2 upregulates expression of the more potent Notch ligands DLL1/DLL4, which boosts signaling and activates antitumor macrophages.

Multiple Postdoctoral positions are available in the laboratories of Demet Araç and/or Engin Özkan at the University of Chicago with expertise in protein biochemistry, cell biology or C. elegans development. Please RT

Paper of the week: A detailed structural and mechanistic elucidation of a new and natural post-post-translational modification---the AMPylation of host phosphoproteins, mediated by a LnaB, a secreted Legionella effector protein. Really fantastic. nature.com/articles/s4158…

Important comment from Aaron Ring. It is no secret that NIH-funded scientists license their technology to biotech companies, this accelerates clinical development and encourages innovation. We need better science communication so this is not surprising or sensationalized.

Bad math: NIH researchers didn’t pocket $710 million in royalties during pandemic - good reality test from Jon Cohen | Science | AAAS science.org/content/articl…

"Here, we report a broad survey of plasmids from hundreds of academic and industrial labs worldwide. We show that nearly half of them contained design and/or sequence errors." Trust nothing; validate everything. biorxiv.org/content/10.110…

Please RT! 🚀 Thrilled to share that I’ve joined Harvard Medical School Harvard Medical School as an Asst. Professor and an Investigator at Brigham and Women's Hospital and the Mass General Brigham Gene and Cell Therapy Institute! 🎉 The AbuGoot lab with Jonathan Gootenberg will work on programmable biology, novel

Engineering synthetic agonists for targeted activation of Notch signaling biorxiv.org/cgi/content/sh… #biorxiv_synbio

bioRxiv Synthetic Biology Amazing! SNAGs' adaptability to biomarkers offers targeted therapy promise. The UAE is emerging as a biotech hub. Exciting times ahead! #Innovation

Want to read about chaperones in the periplasm? My student crafted a metaphor based on basketball :) Guess who the ball hog is? And the MVP? Our TIBS review is now online here: cell.com/trends/biochem…

🚨We are hiring! Tenure-track faculty position (Assistant Professor) in the area of cancer metabolism, diet, tumor-host interactions. Apply below 👇 …cancer-center-careers.hctsportals.com/jobs/1883440-t…

A long waited and must see structure! Congrats to Luca lab!

What an amazing structure of the full length HCV E1-E2 envelope protein! It’s been over a decade since I worked on HCV as a grad student - it’s a so exciting to see this problem solved. Congratulations Prentoe_Lab!

#ESMO24: Retrospective study suggests Covid mRNA vaccines may boost checkpoint inhibitor efficacy, doubling 3-year overall survival in advanced lung cancer patients and raising questions about the importance of cancer vaccine personalization. Endpoints News: endpts.com/esmo24-in-surp…

Do regular old Covid vaccines help make cancer immunotherapy more effective? A very interesting, kind of wild story from Ryan Cross the Science Boss, who digs into the retrospective (CAVEATS!) study, the biology behind it, why the mRNA mechanism itself might be working, and more: