2024's top 10 advances in biology (🧵) 1. Progress in longevity Blocking the pro-inflammatory cytokine, IL11, extended healthspan and lifespan (in mice!) Old mice without IL11 look healthier, they're stronger, and they live longer nature.com/articles/s4158…

Interested in doing a PhD on mechanisms of pneumococcal host-to-host transmission? We have a fully funded PhD available now, deadline 26 January. Come and join us! findaphd.com/phds/project/d…

💊🦠OUT NOW - comprehensive analysis of the propensity of ESKAPE pathogens to evolve resistance to new and in development antibiotics by Csaba Pal, Balint Kintses, Balazs Papp and colleagues. Dive in here... nature.com/articles/s4156…

It hasn't been easy 🥲

This rate of validation suggests that antibodies should be considered non-specific until proven otherwise: 357 validated out of 1,124 tested. .

😨

science.org/doi/10.1126/sc…

PhDone

Two journals tried paying peer reviewers and found increased acceptance, earlier reports, and no change in quality. WHAT A SURPRISE!

In a new Science study, cryo–electron tomography captures the in-cell architecture of the mitochondrial respiratory chain, illuminating how the coordinated action of molecular machines drives life’s fundamental energy conversion. Learn more: scim.ag/4iT8mpD

Excited to see this out in print Mol Syst Biol! A great team effort especially with Christine Moene Nacho Molina 🇪🇺 Arnaud. EMBL Heidelberg embopress.org/doi/full/10.10…

Did you know we have a Pre-Clinical Studies Unit? It offers clinically relevant models of infection and disease for testing new vaccine candidates, drugs and therapies. Find out more here: thepandemicinstitute.org/collaborate/pr…

Easy experiment

LOL

The American Heart Association just published their alcohol recommendations today which line up with the report by the National Academies. Moderate EtOH intake, up to 7 drinks per week (1/day), is without risk (and may be beneficial for cardiovascular outcomes) American Heart Association

Possible scenario: - Nuclear bomb drops - The university: "next week teaching will be done remotely via zoom"

A colleague of mine, an ID physician, dropped by today to say goodbye. He is leaving medicine. I asked him, half jokingly, 'you don't want to help people anymore?'. His answer was serious: 'I learned during the pandemic that people don't want to be helped.'

AI is not on track to eradicate disease in our lifetime. Scientists need to generate more data, but they’re physically limited by how fast they can work. That’s why we’re launching Medra: Physical AI in the lab, doing and optimizing real experiments. Thread👇

Tonight we suspended an employee and are prepared to take additional action in response to a deeply offensive comment posted to the employee’s personal social media account referencing the murder of Charlie Kirk. (1/2)