Utilizing 3D organoid culture to predict the metastatic potential of primary prostate cancer - functional assays for patients PCF Science Howard Soule Society for Basic Urologic Research | SBUR Ganesh Raj Toni Choueiri, MD Katherine Morel CFCE-DFCI

Fascinating work from Wake Forest University. Researchers developed a #3D #organoid model recapitulating the BBB and mimicking normal human anatomy with huge implications for #stroke research nature.com/articles/s4159…

Really interesting work using chip-based 3D models. Given the lack of predictive #models, and only 2 approved symptomatic treatments for idiopathic #pulmonaryfibrosis, clearly, this holds a lot of promise in advancing future therapies nature.com/articles/s4146… x.com/DrSandyWBiomed…

Excellent work from Mathew Garnett's Wellcome Sanger Institute group in oesophagal adenocarcinoma organoid cultures to study clonal evolution and precision therapeutics nature.com/articles/s4146… #cancerresearch #drugdiscovery #organoid #organoids #3dtissue #3dmodel #microphysiological

Visit us PREDiCT - Models Summit in Boston this week and learn how StemoniX products are being used by some of our collaborators! We hope to see you there. Contact us at [email protected] to set up a meeting!

we could link diet, gut bacteria and cancer; medicalxpress.com/news/2017-01-t…

Highlighting the growing role and features of the #TiME which relate to the likelihood of response to #immunotherapeutics go.nature.com/2jlWi41

A fascinating article showing the power of patient-derived #ipsc & #organoids for disease modelling. #kidneydisease #3dcellculture #3dmodels cell.com/ajhg/fulltext/…

It’s now possible to 3D-print an exact copy of a patient’s tumor, right down to its microenvironment and the capillaries that supply blood to it. New from JAX's Derya Unutmaz, MD and Penn State Engineering Science and Mechanics's Ozbolat: jax.org/news-and-insig…

BASF signs 3D bioprinting cosmetics deal with Poietis 3dprintingindustry.com/news/basf-sign…

"The ML models that are developed will then help guide subsequent experiments, providing a tight, closed loop integration of in silico and in vitro methods (an insitro paradigm).” John Carroll - endpts.com/out-to-rethink…

Scientists from Wyss Institute, JanssenUS & @emulatebio publish results showing the translational potential #organonchip to better predict thrombotic side effects of drug candidates. ascpt.onlinelibrary.wiley.com/doi/abs/10.100…

The furture of cellular generation, phenotyping and disease modelling?? #CRISPR derived #organoids x.com/sangerinstitut…

New precision #cancer #model combining #CRISPR & #RCASTVA delivery opens doors to personalized cancer treatment by mimicing the genetic complexity of cancer Nature Communications #tumormodel #preclinical #canceresearch #ResearchHighlight #PrecisionMedicine nature.com/articles/s4146…

Jarno Drost and Hans Clevers review #tumor #organoids and their utility as an alternative model for #cancerresearch in this Nature Reviews Cancer paper nature.com/articles/s4156…

Researchers at Houston Methodist have published data on their "4D" model to show the growth of primary tumours, the formation of CTCs and formation of metastatic lesions linkinghub.elsevier.com/retrieve/pii/S…

Great presentation from GSK's Jason Ekert exploring some of the scaling and automation challenges for #3D #tumor #spheroids. Was fascinating to see how they've informed their emerging bispecific compounds.

Its been a fascinating morning at #3doncology concluded by the Scripps Research Tim Spicer on the use of #3D #spheroids models in discovery. Was amazing to not only see the progress of these platforms in automated ultra HTP formats but thier power over 2D models

"A model is a lie that helps you see the truth - the goal with 3D is to minimise that lie" Asellus CEO Brett Hall & Mitra Biotechnologies's Mark Paris explore how 3D Models are revealing molecular and phenotypic insights over 2D models. #3DOncology18

A fascinating presentation from @dangville on the development a new #3Dmodel done in collaboration with HemoShear for the study of #pancreatic #cancer and #NSCLC. Great to see the novel incorporation of tumor hemodynamics and biological transport #3DOncology18