Out today Cell: Balamurugan Sundaram and Nagakannan Pandian with Thirumala-Devi Kanneganti and team St. Jude Research identified NLRC5 as an innate #immune sensor of NAD+ depletion that drives inflammatory cell death, PANoptosis. authors.elsevier.com/sd/article/S00… Thread👇

New research by Thirumala-Devi Kanneganti in Cell reveals NLRC5 acts as an innate immune sensor and cell death regulator. This understanding has therapeutic implications for treating cancers, infectious diseases and inflammatory disorders. Read more ow.ly/kEPw50Sj8Tn

Cryo-EM structure and description of how #Bedaquiline binds to ATP-Synthase of both host and #mtb!! Incredibly similar binding sites. nature.com/articles/s4158….

Such an important piece of information for those interested in metabolomics!! Van Andel Institute (VAI) nature.com/articles/s4146….

From a brilliant lab! @FendtLab What a great read. cell.com/cell/fulltext/…

Check this out! Our last translational ferroptosis paper from excellent PhD student. Ferroptosis is a targetable detrimental factor in metabolic dysfunction-associated steatotic liver disease | Cell Death & Differentiation #ferroptosis #MASLD nature.com/articles/s4141…

Such a nice opinion piece by Thirumala-Devi Kanneganti Kanneganti Lab covering our publication on Pyroptotic secretome! nature.com/articles/s4142…

How does #macrophagee #metabolism respond so incredibly fast to TLR triggers? Veit Hornung lab have the forst answers- its not just transcription. Phosphorylation of PFKL begins go steer the metabolic switch!

#ImmunoCannibalism! #EveryCellIsAnImmuneCell! The Fuchs lab &co show nature that stem cells sense lipids released by apoptotic cells (& retinoic acid from healthy cells!) & become phagocytic to clear cell corpses & maintain tissue homeostasis! nature.com/articles/s4158…

This paper from @Lammermann_Lab is Bomb!! Entire neutrophils getting trapped by Mast cells to enhance functionality! Reads like beautiful science and feels like an alien abduction movie! MPI of Immunobiology & Epigenetics sciencedirect.com/science/articl…

Nature research paper: Lysosomes drive the piecemeal removal of mitochondrial inner membrane go.nature.com/4fWhHvq

A number of new studies on gasdermin were published recently. Broz Lab and I put together a review to summarise and discuss our current understanding of gasdermins during cell death and inflammation. nature.com/articles/s4155…

📢Call for Applications! BRIC-NII is hosting an "Advanced #Immunology Course" in October for PhD scholars, postdocs, & clinical researchers. It is your chance to learn from experts in the field📚🔬🦠 Apply now! Application Deadline⌛️ 22 Sept 🔗bit.ly/nii_AIC

A beautiful story from the Anderson lab!! Ravichandran Labs Metabolite-based inter-kingdom communication controls intestinal tissue recovery following chemotherapeutic injury: Cell Host & Microbe cell.com/cell-host-micr…

What an incredible piece of work from Calico The giant mouse study explains 1) How the terms “healthy" & "long life” are more nuanced and less interchangeable than we like to imagine. 2) Why/how Dietary Restriction/Fasting might help. nature.com/articles/s4158…

Exciting new findings!! Thrilled to share our latest work in Science Immunology which uncovers how restricted access of newborn Kupffer cells to the bloodstream affects bacterial clearance, increasing risks of dissemination and mortality. As a bonus, we also made it on the cover of

Happy to have been part of this fascinating story at the edge of futuristic science- uncovering geroprotectors using a novel AI platform! Ahuja Lab #AgeXtend nature.com/articles/s4358…

Great start of #EMBOtuberculosis EMBO CCMB Day 1 - Mtb's phenotypic variation Sassetti Lab Neeraj Dhar Giulia Manina Role of B cells - Carolyn King, Heterogeneous host splicing & genetics Dhiraj kumar Sarah Dunstan ++ Dialogue with editors Nature Communications Trends in Microbiology

FROM CELL DEATH TO REGENERATION: What if dying cells -come back to life? Now online The EMBO Journal I tinyurl.com/yp8m7he6 , we aim to answer this question. Here is the journey. If you🩷science, please dont 🛑till the end of 🧵, I promise you will not regret. 1/n