New review on the role of lysosomal lipid metabolism in dementias! Do check it out 🌚 pubmed.ncbi.nlm.nih.gov/33550528/ #Dementia #Alzheimers #lipid #neuroscience

To the biology tweeps: To finish off 2022, Oded Rechavi and I thought it would be fun to hear from you about one paper from 2022 that you think we should all read. One paper per person. A few words why you think is important would be great too.

An intestinal sphingolipid confers intergenerational neuroprotection buff.ly/3YkyvnG (Nature Cell Biology)

'The major #TMEM106B dementia risk allele affects TMEM106B protein levels, fibril formation, and myelin lipid homeostasis in the #ageing human hippocampus' Jun Yup Lee ... Anthony S Don Charles Perkins Centre University of Sydney #lipidomics #proteomics bit.ly/3PJ4w61

My first first-author publication about #TMEM106B in the #hippocampus of ageing cognitively normal individuals has just been published Molecular Neurodegeneration …arneurodegeneration.biomedcentral.com/articles/10.11… #proteomics #lipidomics #neurodegeneration

Excited to share our manuscript showing that loss of #TMEM106B exacerbates #Tau pathology, neurodegeneration and glial activation. We have also observed alterations in neurofilament and microtubule structures. link.springer.com/article/10.100…