Fascinating findings from lab members Lahiru Handunnetthi and Joseph Hamley on the interaction of immune responses and gene expression in brain

The first paper from our lab at MPI for Multidisciplinary Sciences is online! Have a look if you’re interested in very high-resolution (20 bp!) contact matrices and the role of loop extrusion in enhancer-promoter interactions: nature.com/articles/s4146…

Really excited to share our latest paper... fantastic collaboration with Marieke Oudelaar where we developed tiled Micro Capture-C to generate Hi-C like plots at 20bp resolution. Turns out there are nanoscale TADs inside enhancers! nature.com/articles/s4146…

Our latest work online nature — Compatibility rules of human enhancer and promoter sequences Do enhancers prefer certain promoter sequences? Thread 👇 Way to go Drew T Bergman, MD @thouis and team!

Our newest paper with many great collaborators including andi roy and Siobhan Rice, PhD : PAF1 and FACT cooperate with MLL-AF4 to drive enhancer activity in leukemia biorxiv.org/content/10.110…

Preprint online: In my master’s project with Fillip Port Boutroslab, we explored base editors to improve gene inactivation in multicellular organisms, using the crowd favourite #Drosophila. A 🧵about temperature, deaminases, and a missing UNG 👇 biorxiv.org/content/10.110…

Really pleased to share the detailed protocol for Micro Capture-C in nature protocols. It is capable of generating 3C data down to base pair resolution. jdavieslab Hangpeng Li Joseph Hamley MRC MHU MRC WIMM rdcu.be/c8GWN

Congratulations Joseph Hamley and Hangpeng Li for putting together a nature protocols paper for Micro Capture-C! nature.com/articles/s4159…

Excited to present our in-depth protocol for Micro Capture-C, published in Nature Protocols . This innovative method achieves 3C data generation at base pair resolution level! 🧬🎉 Joseph Hamley James Davies jdavieslab MRC WIMM

In 2016 I looked after a girl who died during a transplant for HbE beta-thalassaemia. I am overwhelmingly pleased that we have been able to correct HbE with near 100% efficiency using base editors. nature.com/articles/s4146… Brilliant work from Mohsin Badat @Montytrench jdavieslab

Multiplex-genome architecture mapping (multiplex-GAM) facilitates rapid, unbiased and ligation-free determination of chromatin interactions, as compared to Hi-C. Prof Ana Pombo Rob Beagrie Scialdone Lab Lonnie R Welch PomboLab Helmholtz nature.com/articles/s4159…

Buckle up! We're in for a wild ride today. A new Nature Metabolism paper by scientists from China adds a surprising twist to the long-known FTO GWAS story. The FTO locus (16q12.2) is the first ever GWAS locus to be associated with obesity and even after 16 yrs now, scientists

It is fantastic to finally be able to see this paper in print, great collaboration with everyone: nature.com/articles/s4146… MLL-AF4 creates high density enhancer interactions by recruiting a transcription complex including FACT and PAF

Our work from my master’s project exploring cytosine base editors for gene editing in Drosophila is now published Science Advances (my first first-authorship🎉) science.org/doi/10.1126/sc… There are several additions since the preprint, so read along for a 🧵with the main points:

Very happy and honored to present our work from my postdoc project in @DaanNoordermeer lab I2BC Paris-Saclay on CTCF clustering at TAD boundaries and the novel multi-contact 3C assay: Nano-C – now published Nature Communications. nature.com/articles/s4146…. A nice 🧵 written by Daan 👇

We are looking for an RA to join the lab to work on a fantastic genomics project! jobs.ac.uk/job/DCH089/res… Closing date next week! Please RT - thank you!

It was wonderful to see the Seminar Room so busy yesterday for our Student Presentation Day! Congratulations to everyone who presented, especially Elizabeth Horton (Rehwinkel Group), Isaac Walton (Wilkie Lab) and Joseph Hamley (jdavieslab) who have been shortlisted for the

KJ Patel CAM-OX traveller Anne Goriely RDM Oxford Adam Mead David Cruz Hernandez 🌵 Vyas Lab Lauren Murphy Beth Psaila In the 2nd scientific session of the day, chaired by James Davies, three PhD students are battling it out to win the Ita Askonas Medal and a £500 prize! 🏅💸   Good luck to all three finalists, Elizabeth Horton (Rehwinkel Group), Isaac Walton (Wilkie Lab) and Joseph Hamley