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Foreign DNA: May I join? Chromosome: Why? F: bc your house is great for raising a family C: Have a passport? Funabiki lab Rockefeller University seeks for a postdoc who wants to study what makes chromosome's house attractive, what's the passport & consequences of losing it. Please RT!

Congratulations to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless for winning Nobel Prize in Chemistry 2022. Check our these relevant collections: Azides for “Click Chemistry”: enamine.net/building-block…  Fully Functionalized Probe Library: enamine.net/compound-libra…

Congratulations to @elissaa_fink from UCSF School of Pharmacy on her 1st place poster prize at the 8th GPCR symposium, sponsored by RSC Chemical Biology! She used computational methods to discover new compounds with pain-relieving effects as potential opioid alternatives. @BShoichet RSC BMCS

Please look at our new paper about ZINC-22. I am grateful in advance for your helpful feedback... doi.org/10.26434/chemr…. thanks to @NIGMS GM133836

ZINC-22 (cartblanche22.docking.org) now has over 4.5 billion tangible compounds in biologically-relevant 3D formats ready for docking. They are available in AWS and OCI as well as at UCSF.

Whoo hooo!! Congrats to Yongfeng, Can, Jonathan and others--major structural insights into a novel GPCR! nature.com/articles/s4158…

And here it is: how and why DREADD-based chemogenetics works. Shicheng Zhang (张世成) solved structures with cryo-EM analysis by Jon Fay and MD simulations by Ryan Gumpper Amazing work--have waited since 2005 to understand why DREADDs work as well as they do! nature.com/articles/s4158…

Please retweet!📢 The Liu Lab is seeking 2 new research assistants starting immediately! This position is ideal for those looking to gain research experience in biophysics & biochemistry, close mentorship, and an introduction to the Tri-I campus in NYC. See attached for details!

Thanks, Alina!

I also created this little cartoon that sums up our paper!

Excited to share our review on Protein State-Dependent Chemical Biology in Wolf Prize Special Issue of Israel Journal of Chemistry honoring 2022 recipients Ben Cravatt, Bonnie Bassler, and Carolyn Bertozzi onlinelibrary.wiley.com/doi/full/10.10…

Great to learn of many researchers and companies using the data from our Mega-scale folding stability paper! If you are using these data it would be fantastic if you could register here forms.gle/wuHv8MKmEu4EEM… so we can show funders why this is important!

Thrilled to start my own lab at U Chicago in the Departments of Radiation & Cellular Oncology and Chemistry! Glad to also be a member of the Comprehensive Cancer Center. We're actively recruiting postdoc and RA with expertise in chemical biology and protein/antibody engineering.

We were incredibly disappointed with the lack of code or executable accompanying the publication of AF3 in nature . This contradicts scientific principles of the ability to evaluate, use, and build upon existing work. zenodo.org/records/111798…

Hundreds of thousands of potential psychedelics discovered by docking against predicted and real structures of 5-HT2A #psychedelics "AlphaFold2 structures guide prospective ligand discovery" science.org/doi/10.1126/sc…

Very happy to share our new work out today in Science Magazine ! Truly a fascinating study and very surprising results! Congrats to all involved JK Lyu @NKapolka BryanRoth @BShoichet and many many others. science.org/doi/10.1126/sc…