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In a phase 1 study involving patients with Danon disease, AAV9.LAMP2B gene therapy appeared to be safe, increased cardiac LAMP2 expression, and was associated with clinical improvement over 24 to 54 months. Read the full study results: nej.md/40IBJVh Science behind the

I found a very large tuning fork in our ICU. Can anyone educate this foolish cardiologist as to what it could possibly be used for?

When you go to submit your review of a paper and find they removed you as a reviewer an hour ago 🤦‍♂️

Was today described as the congestive cardiac failure registrar. Niche.

ahajournals.org/doi/10.1161/CI… XBP1 and EDEM2 identified as protective against myocardial lipid accumulation and downstream hypertrophy, fibrosis and myocardial stiffness in a rodent model of HFpEF. Metabolic answers for metabolic conditions!

jacc.org/doi/abs/10.101… I think the take home message here is "give more diuretics" but good to recap the different modalities, and I wonder if I under use tolvaptan?

Implantation of an intra-aortic balloon pump (IABP) did not improve 60-day survival or bridge to heart replacement (HRT) therapies in patients w/ HF-CS compared to standard care. #ACC25 Read the journal scan to learn more: bit.ly/4c73BG4 #JACC JACC Journals

This is good but most are on two lines, so slightly false advertising there.

nature.com/articles/s4159… FRESH-UP study. Fluid restriction to 1.5L vs liberal intake in HF. NO difference in QoL over 3 months. NO increase in HF hospitalisation, diuretic doses, BNP or weight. BUT median NYHA II, mean EF 40%, median fruse 40mg.

Gdbo (X2)

What a week! Three cities, three conferences: one abstract presented, two talks given and one session chaired! Thanks The ISHLT British Society for Heart Failure #theFword and CambridgeCardio !

Sensational debate by Holly & Will Watson Highly entertaining and a great end to day 1 at Cardiff BSH MDT #mdt2025 #freedomfromfailure #25in25 British Society for Heart Failure #theFword BSH Nurse Forum Welsh Heart Failure Society

Pathophysiology and clinical use of agents with #vasodilator properties in acute heart failure. A scientific statement of the #HFA of the European Society of Cardiology (ESC) onlinelibrary.wiley.com/doi/full/10.10… Marco Metra #EJHF Henry Han Giuseppe Galati Amr Abdin

Fascinating piece of research by Divaka Perera & team…. Raises questions re pressure wire assessment of left main AND whether assessment of coronary microcirculation should be multi territory on a routine basis!

Circulation Research Interorgan Crosstalk in #HF & #Cardiometabolic Diseases Compendium CV, #Kidney, #Liver, & Metabolic Interactions in #HF: Breaking Down Silos ahajrnls.org/3ZtHfJQ by Roger Foo Joseph hill Faiez ZANNAD Shahzeb Khan Jennifer Ho Leah Kosyakovsky et al

Why do we call it ejection fraction when it’s a percentage?