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Meet MagLOV: an engineered protein that responds STRONGLY to magnetic fields. This is a fluorescence timelapse of MagLOV in E. coli. We're waving a (small) magnet under the plate. Can you tell where the magnet is? Want some? It's on Addgene now! addgene.org/219957/

Introducing Cradle, co-founded with Hunter C Davis. We're building reversible cryo technologies. Think the hibernation pods you see in space movies for long-term travel - we want to build that. We’ve raised $48M, built a world-class team of scientists and engineers,

Arjun Raj Mark Budde (hiring wetlab, DMs open) 🦕🏆 Uri Alon In case it's helpful to anyone, I posted the evolving set of talk tips that I share with my lab on our website. Scroll to bottom of this page: elowitz.caltech.edu/teaching. (It was once "10 commandments" but has since expanded to 25...the slide titles are currently number 5)

Ready to dive in to help a group of brilliant and passionate people do their best work to advance science, technology and medicine? Join our lab at Caltech and HHMI in Pasadena, CA as our #LabManager! Apply here: tinyurl.com/labmgrdive

Can we image opaque organs in 3D at the capillary and cellular scale? Yes, w/nonlinear sound-sheet microscopy! Congrats to Baptiste Heiles 🔊🐭🧠 and co-authors on developing the first fast, high-resolution and volumetric biomolecular ultrasound imaging method. biorxiv.org/content/10.110…

How could we check if a gene therapy reached the desired brain region? Here, we noninvasively measure gene delivery and endogenous gene expression in specific brain sites with ultrasound-released synthetic serum markers. science.org/doi/10.1126/sc…

Congrats to my friend and colleague Guosong Hong for his stunning and original discovery, published today in Science, on clearing tissues *in living animals* with a common food dye! The dye is tartrazine, used in Doritos! science.org/doi/10.1126/sc…

Technician Opening in our lab! 🧑‍🔬 Join us! Please share. phf.tbe.taleo.net/phf03/ats/care…

Where do they where do they go? 🎤 Can we track a T-cell therapy with ultrasound inside tumors? Yes, with the latest lentivirally delivered acoustic reporter genes based on #gasvesicles! 🔊 Congrats to @shyreeene and colleagues on this advance! biorxiv.org/content/10.110…

From CAR-T cells to bubble-T cells🧋We took gas vesicle proteins from floating cyanobacteria and expressed them in T cells to track their location as they home to tumors. This tool will help us understand the dynamics of cell-based therapies deep inside the body.

Cute story alert!🧵Caltech two clueless office mates (DanPiraner & I) created a tool to control cells with ultrasound. As postdocs (UC San Francisco & Institute for Protein Design), we teamed up again (with Majo Duran & Adam Chazin-Gray) to build a tool for engineered cell signaling nature.com/articles/s4158…

I’m excited to share how a modular synthetic receptor called SNIPR opens new possibilities for immunotherapy by sensing both tumor-secreted factors and synthetic computationally designed soluble proteins: nature.com/articles/s4158….

What happens when you can take videos of acoustic proteins in 3D inside the body? 🧊 You can see things like the flow of CSF in the brain!🧠 Congrats to Sunho Lee, co-senior author Claire Rabut, and colleagues on "Takoyaki" 3D ultrasound.🥟 #gasvesicles biorxiv.org/content/10.110…

Congrats to Dr. @shyreeene Shirin Shivaei on defending her PhD thesis Caltech on viral expression of #gasvesicles in T-cells and neurons in vivo -- allowing ultrasound to image previously invisible biology! 🍾Proud of your fearless pursuit and success!

Job Opening! The Shapiro Lab at Caltech is looking for a Research Technician to accelerate our neuro🧠 efforts. Join us! Please RT. Apply here: tinyurl.com/neurotechnician

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS, indeterminate dendritic cell histiocytosis

A big step forward for biomolecular ultrasound! 🔊 Congrats Baptiste Heiles 🔊🐭🧠, David Maresca at TU Delft and collaborators! #gasvesicles

Congratulations to Dr. Erik Schrunk on defending his PhD in Chemical Engineering Caltech! 🍾 Erik added programmable covalent functionality to #gasvesicles to map their location in cells and spatially actuate chemistry. 🧪

New in Science Magazine, we present DISP—an imaging guided deep-tissue in vivo sound printing platform that allows spatiotemporally controlled printing of diverse biomaterials. Congrats to Elham (Emma) Davoodi and the team! Caltech Caltech Division of Engineering & Applied Science Caltech Medical Engineering science.org/doi/10.1126/sc…

Excited to share our new work in Science Magazine! We present an in vivo sound printing platform that uses focused ultrasound to pattern functional biomaterials deep within the body, non-invasively and in real time. science.org/doi/10.1126/sc… #3DPrinting #Ultrasound