New paper alert! Scientists in Clemens Plaschka’s lab at the IMP and Julius Brennecke's lab at IMBA imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys

Unlocking Hidden Biomolecular Conformational Landscapes in Diffusion Models at Inference Time 1. Researchers at Stanford University introduce ConforMix, an innovative algorithm that enhances the sampling of biomolecular conformational distributions using diffusion models. This

A primer on GFP and esmGFP owlposting.com/p/a-primer-on-… with evo scale now boiling into the CZI conglomerate, it is a good time to re-post this article from the archives. this one discusses the novel GFP protein that the team made 1.5~ years back. the world was so young back then

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Comparison of Molecular Recognition in Docking Versus Experimental CSD and PDB Data #Docking pubs.acs.org/doi/10.1021/ac… #JCIM Vol65 Issue19 #compchem

My grandfather bought an apartment from Blackrock on a 200 year mortgage. 1 bed, 1 bath, no car. My family has been paying it off for 80 years now. We're nearly half way there. We're so grateful that we're not renting. And in just 2 more generations, we'll own it outright.

Israeli citizen Miriam Adelson bought the Dallas Mavericks for $3.5 billion; now she’s buying politicians. She’s spending millions in Kentucky to buy Ed Gallrein, my primary opponent, a Congressional seat in Kentucky. Why? Because I won’t vote to send your tax dollars overseas.

A protein from a modern shark gene explains the evolution of the adaptive immune system shared by all vertebrates. als.lbl.gov/sharks-shed-li…

Accelerated adaptive laboratory evolution: A tool for evolutionary biotechnology "the most suitable approach for ALE library construction and/or in vivo mutagenesis summarized in Table 3" sciencedirect.com/science/articl…

A reminder that the abundance of 'housekeeping' proteins varies significantly across cells and tissues. GAPDH is often slandered as a 'housekeeping' protein, and its abundance varies significantly across human tissues. How do you define a 'housekeeping' protein ?

(1/n) Can diffusion models simulate molecular dynamics instead of generating independent samples? In our NeurIPS2025 paper, we train energy-based diffusion models that can do both: - Generate independent samples - Learn the underlying potential 𝑼 🧵👇 arxiv.org/abs/2506.17139

Can machine learning enable 100-plex cryo-EM structure determination? (Ellen Zhong, Ep #5) (links in reply) this is a podcast filmed with Ellen Zhong, a computer science professor at Princeton, and one of the giants (if not outright creators) of the field of deep-learning

Today, we're announcing Episteme, a new type of R&D company that recruits exceptional scientists to pursue high-impact ideas. Science isn’t bottlenecked by the availability of talent, but by places where they can do their best work. Scientific progress has driven human

it would seem that the value of the raw chicken comes from its potential. a raw chicken's destiny has not yet been written, whereas a rotisserie chicken's fate is sealed.

arxiv.org/abs/2508.19385…

What if molecules or cells could be modeled as truly entangled, in which each particle’s motion shaping the others? Meet EntangledSBM, a Schrödinger Bridge framework for interacting second-order dynamics! ⚛️ 📜: arxiv.org/abs/2511.07406 💻: github.com/sophtang/Entan… In her recent

Ben Shapiro has spent 10 years fighting against “identity politics.” Then he married an Israeli, moved to a 99% Jewish neighborhood, and devoted his entire career to supporting Israel. He’s playing for his own team, but he says you’re evil if you play for yours.

If H-1B visas were about bringing the best talent on the planet, it wouldn’t be 71% from India. There would be tons of Germans, Polish and Russians receiving the H-1B visas each year. H-1B is a scam for cheap slave labor.

Very excited that our AlphaProof paper is finally out! It's the final thing I worked on at DeepMind, very satisfying to be able to share the full details now - very fun project and awesome team! julian.ac/blog/2025/11/1…