Thanks for sharing our paper on the very low risk of T cell malignancies driven by insertional mutagenesis in a paediatric/young adult CART setting. Impt to contrast with the non-negligible risk of secondary myeloid malignancies seen with CART as with any anti-leukaemic therapy…

A study in Nature Immunology finds that a single injection of CAR T cells, designed to target drivers of allergic reactions, represses the signs and symptoms of allergic asthma in mice for at least a year. go.nature.com/3VeWuVg

Exciting news for CBDI! Cincinnati Children’s is developing an Applied Gene and Cell Therapy Center, which will increase clinical trials of innovative drugs and biological therapeutics for patients with cancer, blood diseases or genetic disorders: scienceblog.cincinnatichildrens.org/60m-applied-ge…

All-in-one Hangzhou Protocol: killing four birds with one stone | ⁦Cell⁩ ⁦IACH⁩ ⁦Florent Malard⁩ nature.com/articles/s4142…

Immunology, made simple...

High-dose anakinra (up to 12 mg/kg/day) for refractory cytokine release syndrome (CRS)/immune effector cell-associated neurotoxicity syndrome (ICANS) was safe. Higher anakinra dose may be associated with faster CRS/ICANS resolution. Read more: astctjournal.org/article/S2666-…

🚨 7th CAR T Cell #immunotherapy approved by #FDA obecabtagene autoleucel for adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia fda.gov/drugs/resource…

Beyond the blood: expanding CAR T cell therapy to solid tumors - Ugur Uslu Carl June go.nature.com/3Z4eBiQ

Scaling the World`s Highest Peak. A Thread of Sorrows🧵 The congestion at the summit is overwhelming

Advances in cancer immunotherapies Cell

In this RCT, people w/ HbSC disease were treated w/ a year of hydroxyurea or placebo. Dose-limiting toxicity occurred in 33% of participants on hydroxyurea & 11% on placebo. Hydroxyurea treatment was associated w/ fewer vaso-occlusive pain events. eviden.cc/3Zn494X #ASH24

Blinatumomab in Standard-Risk B-Cell Acute Lymphoblastic Leukemia in Children | New England Journal of Medicine nejm.org/doi/full/10.10…

Such a privilege to have the man himself come and discuss the poster. Thank you ⁦⁦andi roy⁩ for capturing the moment. Thanks Angus and ⁦⁦Jack Bartram⁩.

Five patients with hemophilia A had dramatic reductions in bleeding episodes after undergoing autologous HSCT with lentiviral vector–transduced cells encoding a CD68-targeted factor VIII transgene. Full trial results: nej.md/3Vk5xUA #ASH24

Very excited about this paper! This was a wonderful collaborative project with Karadimitris lab ⁦Imperial Department of Immunology & Inflammation⁩ . Thanks to funders ⁦Science and Innovation at Cancer Research UK⁩ and ⁦Research at Children with Cancer UK⁩ . On #CCAM , we hope this brings us closer to curing #InfantALL ox.ac.uk/news/2025-09-0…

Original Article: Intravenous Rehydration for Severe Acute Malnutrition with Gastroenteritis (GASTROSAM trial) nej.md/3TjfSP7 Editorial: Data versus Dogma — Safety of Intravenous Rehydration in Severely Malnourished Children nej.md/4mHwxs3 #CriticalCare

Today's Nobel Prize for Physiology or Medicine relates to research on regulatory T cells nobelprize.org/prizes/medicin… For readers interested in harnessing the biology of regulatory T cells to treat disease, here's a comprehensive review nature.com/articles/s4157… rdcu.be/eJHU8

For readers interested in finding out more about in vivo CAR-T therapies such as those at the centre of the $1.5 billion acquisition of Orbital Therapeutics by Bristol Myers Squibb today, here's a comprehensive review rdcu.be/eKnwV nature.com/articles/s4157…

New NEJM One-shot gene therapy for a type of congenital deafness enabled some children to hear for the first time, and 3 of 12 kids achieved normal hearing nejm.org/doi/full/10.10…

Original Article: Mass Administration of Azithromycin to Infants in Mali to Reduce Mortality (LAKANA trial) nej.md/3W9ykeD #Pediatrics #PublicHealth