Unlocking the predictive power of blood tests! 🩸🔬 UK Biobank study reveals that plasma protein signatures can predict disease onset years in advance for over 60 common and rare conditions, including cancer and heart disease. Quick Read: cbirt.net/unveiling-dise… #Bioinformatics

New study led by talented post doc in the lab Aaron Havas : 1) aged tissues at increased risk of cancer due to "precarious balance"; 2) age-activated IFN signaling is an adaptive response to prevent cancer in older tissues, but w/ maladaptive consequence. tinyurl.com/2k4nzs49

In TIMI trials CHIP is associated with incident but not recurrent coronary events and the presence of CHIP does not identify patients who will derive greater benefit from commonly used CV therapies #CVD #heartdisease Nature Medicine nature.com/articles/s4159…

On the new Alzheimer's amyloid antibody drugs "Clinically, short-term effects are small, adverse events are frequent, treatment regimens are burdensome, and, crucially, long-term effects are unknown." alz-journals.onlinelibrary.wiley.com/doi/full/10.10…

Targeting the muscarinic M1 receptor with a selective, brain-penetrant antagonist to promote remyelination in multiple sclerosis | PNAS pnas.org/doi/10.1073/pn…

Introducing a resource of mtDNA copy number (mtCN) across ~10k human donor-tissues (GTEx), 20 murine tissues, and 173 cancer cell lines. Insights emerge by integrating mtCN w/other large-scale measures, e.g., DepMap cells w/high mtCN resist loss of GPX4. pnas.org/doi/10.1073/pn…

The genomic landscape of 2,023 colorectal cancers nature.com/articles/s4158…

As leaders, we must focus on how to unite our teams to accomplish shared goals together. #ThursdayThoughts

How sleep resets the brain for new memories Discovery of new type of hippocampus neuron firing called BARRS (barrage of action potentials) that go silent during deep sleep science.org/doi/10.1126/sc… science.org/doi/10.1126/sc… Science Magazine

Dr.GPCR University courses are back 🎓 Dr. Terry Kenakin will be teaching 2 courses about “Principles of Pharmacology,” a 9-week journey designed for anyone interested 🙌 Spots are limited, so don’t wait too long to register! 😉 ❇️bit.ly/4dGEkSY #gpcr #drgpcr

A new review on obesity The Lancet thelancet.com/journals/lance… Ildiko Lingvay Priya Sumithran

The fruits of failure | Science science.org/doi/10.1126/sc…

‘Then I Am Myself the World’ ponders what it means to be conscious sciencenews.org/article/then-i…

nmn.com/news/protein-r…

youtube.com/watch?v=cE609L…

ScholarGPS scholargps.com/scholars/62883…

It's nice to see that our work on the association between Filamin-C (FLNC) and Frontotemporal dementias has been receiving so much interest (700 reads and counting....). Thanks to everyone who has taken the time to read our paper. researchgate.net/profile/Stuart… via @researchgate

...if you'd like to read more about the links between Filamin-C (FLNC) and #FTD (#Frontotemporal #dementia) then here's a link for you. actaneurocomms.biomedcentral.com/articles/10.11…

....interesting collection of articles from Eric Topol Slowing the Pace of Brain Aging, by Eric Topol open.substack.com/pub/erictopol/…

....here's my latest page update from the excellent Semantic Scholar from Ai2 . If you've not tried it, it's one of the most advanced platforms for academic research analysis. semanticscholar.org/author/Stuart-…