Avilés, Goodrich, Cepko, Xue et al. Harvard Medical School report that the loss of FAT3 acts via its intracellular domain and retinal bipolar cells to affect mouse electroretinography (ERG) responses and visual perception of high-frequency flickers. hubs.la/Q035dRd80

NIH While the indirect rates have in general been to high, it reflects that the direct costs have not been inflation-adjusted for decades. If you do this, put the money back into direct costs that actually fund the research. This is a total disaster for all universities.

It seems few people know what an “indirect cost” is or why it has to be 40-60%. The reason the government forced universities to raise their indirect costs up to (typically) 40-60% was to force a huge amount of regulations on the universities while also minimizing the

Maturation, structure, and dynamics of human cone PDE6C important for photopic vision More details and link to join in our bio!

Congratulations to MCIP PhD Candidate, Lesly Palacios Castillo who won Best Student Talk at this year's MCIP Annual Retreat!

Congratulations to MCIP PhD Candidate, Noelle Morrow who won Best Student Poster at this year's MCIP Annual Retreat!

Read about the SEI Joan and Irwin Jacobs Retina Center researchers & UC San Diego electrical engineering graduate students working together to develop better computer vision, artificial intelligence & image processing tools to advance patient care. shileyeye.ucsd.edu/news-events/327

The professor of neurobiology at David Geffen School of Medicine at UCLA has been selected as the recipient of the 2025 Pradel Reseach Award for her contributions in the understanding of the nervous system. newsroom.ucla.edu/dept/faculty/a…

Haruhisa Okawa and Alapakkam Sampath study Temporal Transformation of the Rod Single-Photon Response in the Retinal Circuitry, iovs.arvojournals.org/article.aspx?a…. USC A.P. Sampath UCLA Stein Eye Institute

Our latest on GPCR function in the brain. We report that glutamate receptor mGlu4 needs to be properly positioned at synapses of cholinergic interneurons in NAc by cell adhesion molecule ELFN1 to regulate opioid reward. pnas.org/doi/epub/10.10…

The ON/OFF dichotomy is fundamental to visual processing. In a new study led by Flori Soto, we identify a conserved molecular mechanism establishing the OFF pathway. rdcu.be/eikoa

Excited to share our work on highly water-dispersible, biodegradable conductive polymers for injectable hydrogel bioelectronics! Now published in Nature Communications 🔗 nature.com/articles/s4146… #bioelectronics #hydrogels #biomaterials

We have innovated design of templates for CRISPR/Cas9 editing which allows efficient introduction of epitope tags in vivo. It is a simple hack which we hope to be broadly useful. Work by talented graduate student Chuanping Zhao. nature.com/articles/s4146…

Check out the latest paper on a weird jawless fossil fish, and this time we were able to recreate a full 3D model! Thank you Lisa Schnetz, IvanS, Sam Giles, Richard Dearden et al. for having me on the paper Science at the Natural History Museum #fossilfish #CTscan #palaeotology

Happy to share our recent work on a conductance that shapes substantially the output of rod photoreceptors. The role of the Ca2+-activated Cl- conductance in the membrane potential and light response of mouse rods jneurosci.org/content/early/…

Pleased to share the latest work from the laboratory by first authors Paul Bonezzi and Rikard Frederiksen. See video abstract by Paul! Photoreceptor degeneration induces homeostatic rewiring of rod bipolar cells: Current Biology cell.com/current-biolog…

In eLife - the journal: Version 2 of Investments in photoreceptors compete with investments in optics to determine eye design doi.org/10.7554/eLife.… Much improved - points clarified, arguments strengthened. Thank you editors, referees and above all my co-author Fran Heras

We found that endogenous ligand for GPR139 is opioid peptide dynorphin. With this, GPR139 may not be an orphan any more but the 5th opioid receptor. Heavy lift by talented Xiaona Li with great thanks to all who contributed! nature.com/articles/s4146…

Evolution’s eye game is wild, but mollusks take it to another level Using CRISPR, we now have a new model in apple snails to dissect how nature rebuilds complex organs like the camera-type eyes we humans possess Evolution, it turns out, doesn’t just innovate, it rewinds,

At #MBL Visual Neuroscience course w/ Anna Jansson Anna Jansson, Angel Robles-Gomez & Leonor Afrima. Using 2P microscopy to image transfer of visual signals into & out of bipolar cells in retina of larval zebrafish. Great fun! Thanks to Directors Rich Kramer & Schwartz Lab