New data confirm that #APOE4 homozygosity is a major genetic cause of #Alzheimersdisease, necessitating the development of specialized research strategies, treatments and clinical trials. News & Views from Yadong Huang and colleagues Gladstone Institutes UC San Francisco nature.com/articles/s4159…

Check it out! Our APOE uncoupling story is now officially published. #ENDALZ MODEL-AD The Jackson Laboratory kate foley, phd Greg Carter Ravi Shanker Pandey Peter Bor-Chian Lin Howell Lab Gareth Howell alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

“I do not see anything in this paper to justify the claim that carrying two copies of ApoE4 represents some ‘distinct genetic form’ of Alzheimer’s disease,” said Prof David Curtis, an honorary professor at the University College London theguardian.com/society/articl…

APOE ε4 carrier status modifies plasma p‐tau181 concentrations in cognitively healthy super‐seniors - Cooper - ⁦Alzheimer's & Dementia Journals⁩ alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

Final couple of days to apply for our 3-year postdoc in genetic epidemiology to address the role of apoE in Alzheimer's disease. NB: new link to the job ad here: ucl.ac.uk/work-at-ucl/se…

The role of dementia in the association between APOE4 and all-cause mortality: pooled analyses of two population-based cohort studies - The Lancet Healthy Longevity The Lancet Healthy Longevity thelancet.com/journals/lanhl…

Specification curve analysis to identify heterogeneity in risk factors for dementia: findings from the UK Biobank | ⁦BMC⁩ Medicine | bmcmedicine.biomedcentral.com/articles/10.11…

APOE3 Christchurch Heterozygosity and Autosomal Dominant Alzheimer’s Disease | New England Journal of Medicine NEJM nejm.org/doi/full/10.10…

Apolipoprotein E in Alzheimer’s disease trajectories and the next-generation clinical care pathway | ⁦Nature Neuroscience⁩ nature.com/articles/s4159…

Very low levels of ABCA7 in the cerebrum and Alzheimer’s disease onset between the ages of 60 and 80 independently of APOE academic.oup.com/jnen/advance-a…

Proteomic analysis of Alzheimer’s disease cerebrospinal fluid reveals alterations associated with APOE ε4 and atomoxetine treatment | Science Translational Medicine science.org/doi/10.1126/sc…

Multifaceted roles of APOE in Alzheimer disease | Nature Reviews Neurology nature.com/articles/s4158…

Sex, racial, and APOE -ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer's disease - PubMed pubmed.ncbi.nlm.nih.gov/38915636/

Our lab's first manuscript just dropped on bioRxiv! The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases uncovers cholesterol as a regulator of astrocyte reactivity impaired by ApoE4 biorxiv.org/content/10.110…

Sex-dependent APOE4 neutrophil–microglia interactions drive cognitive impairment in Alzheimer’s disease | ⁦Nature Medicine⁩ nature.com/articles/s4159…

Altering heparan sulfate suppresses cell abnormalities and neuron loss in Drosophila presenilin model of Alzheimer Disease: ⁦iScience journal⁩ cell.com/iscience/fullt…

📣 Happy preprint Monday! APOE, the strongest Alzheimer's disease (AD) risk gene, is upregulated in microglia. However, humans have uniquely evolved three distinct APOE isoforms. What does this mean in terms of the microglial response in AD? biorxiv.org/content/10.110… 1/9

The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia in a xenotransplantation model of Alzheimer’s disease | ⁦bioRxiv⁩ biorxiv.org/content/10.110…

The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases uncovers cholesterol as a regulator of astrocyte reactivity impaired by ApoE4 ⁦bioRxiv⁩ biorxiv.org/content/10.110…

APOE×BDNF Interaction and Poorer Cognitive Outcomes Among Veterans With Mild Traumatic Brain Injury: An Exploratory Study | The Journal of Neuropsychiatry and Clinical Neurosciences psychiatryonline.org/doi/10.1176/ap…