Preprint on "BWT construction and search at the terabase scale". We can compress 100 human genomes to 11GB in 21 hours, find SMEMs with it, do affine-gap alignment and retrieve similar local haplotypes. 7.3Tb commonly sequenced bacterial genomes ⇒ 30GB arxiv.org/abs/2409.00613

I am predictably triggered by this 1 billion loops benchmark thing. If you vectorize the Python, it's ~10x faster than Rust, C, etc. With less code! The point here is _not_ that Python itself is fast. It's not! The point is that Python makes this accessible, and even the norm!

HEALTH ALERT: Meningococcal case - 5 December 2024.

🔥 🇦🇺

Today I was sent the following cool demo: Two AI agents on a phone call realize they’re both AI and switch to a superior audio signal ggwave

Super excited to share that a new version of clipper is available now. 🔥 Multi monitor support 🔥 Performance enhancements using Angular Signals Give it a try - github.com/anuradhawick/c…

Realfreq, a framework for real-time base modification analysis for nanopore sequencing, is now published in Bioinformatics. Written efficiently using C, a laptop can keep up with a Oxford Nanopore MinION sequencer, and a desktop a PromethION 2 solo flowcell. academic.oup.com/bioinformatics…

Our tool “CapBuild: a cloud-native tool for adeno-associated virus capsid engineering” is now published. Check it out now! #bioinformatics #engineering #webserver academic.oup.com/nar/article/do…

New metagenome assembler for @Nanopore R10 and PacBio HiFi reads from Jim Shaw

We released two open-weight reasoning models—gpt-oss-120b and gpt-oss-20b—under an Apache 2.0 license. Developed with open-source community feedback, these models deliver meaningful advancements in both reasoning capabilities & safety. openai.com/index/introduc…