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A6: Histologic spectrum of endometrial carcinomas with HER2 amplification. nature.com/articles/s4137… #HER2, #PathTwitter, #GynPath, and #pathx

A7: Mirvetuximab soravtansine was recently approved for adult patients with FRα positive, platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer who had received prior treatment based on the MIRASOL trial. fda.gov/drugs/resource… #HER2, #PathTwitter

A7: NCCN guidelines mention PD-L1, MSI/MMR status, HER2 expression, NTRK gene fusion, RET gene fusion as actionable biomarkers in cervical cancer. nccn.org/professionals/… #HER2, #PathTwitter, #GynPath, and #pathx

A7: Don’t forget to test for folate receptor alpha or FRα in patients with advanced epithelial ovarian, fallopian tube, or primary peritoneal cancers. Test may also be called FOLR1 for folate receptor 1 protein. #HER2, #PathTwitter, #GynPath, and #pathx

A6: Images of HER2 staining patterns and heterogeneous staining in gastric-type endocervical adenocarcinoma. modernpathology.org/cms/attachment… #HER2, #PathTwitter, #GynPath, and #pathx ASCP Anne Mills Dr. Bui Pathologist🌼

A7: MORAb-202 is another ADC-targeting FRα and it consists of farletuzumab & eribulin with a cathepsin B cleavable linkage. This ADC is being studied in ovarian cancer & other FRα tumors. ascopubs.org/doi/10.1200/JC… #HER2, #PathTwitter, #GynPath, #pathx Anne Mills Dr. Bui Pathologist🌼

A7: MMR/MSI testing is essential in endometrial cancer. Results’ll guide treatment decisions & clinical trial enrollment opportunities. Other important targetable biomarkers include HER2, P53, folate receptor alpha, tumor mutation burden gynecologiconcology-online.net/article/S0090-…  #HER2 #GynPath

Please join us for our virtual open house for #pathmatch2025! Tuesday, August 27th from 6-7pm EST on Zoom: virginia.zoom.us/j/93441035443?… We can’t wait to meet everyone!

We’re so looking forward to our open house tonight! Come for an introduction by our lovely PD Anne Mills and stay for a Q&A with residents. In the meantime, check out our website for information on our curriculum, residents, and life in Cville. med.virginia.edu/pathology/educ…

Greatly enjoyed being a guest on ModPathChat with George J. Netto MD to discuss our recent review article on a rapidly evolving topic of assessing multiple lung cancers. Thank you George for having me! (video recording will be posted soon) (** please note at the end, when I say AJCC 7th

Frozen section readiness session on GI cases with our Chair Dr. Chris Moskaluk. This is one of an 8-part series is geared towards #UVAPath senior residents & fellows to help them prepare for indirect supervision on frozen call. Junior trainees also welcome, of course!

September has arrived, which means the return of our beloved Mills Conference, where PGY1s answer questions about unknown questions. Congrats to our PGY2s on their last Mills in the hot seat and showing the new PGY1s how it’s done!

Congratulations to UVA Pathology resident Aleksander Luniewski for being selected as a blue ribbon finalist in the scientific category at #ASCP2024 poster presentation. Great job Alex!!

Can Pap cytology aid in endometrial CA detection in Lynch patients? Some promise, some caveats: See our Journal of American Society of Cytopathology study! Findings caution against primary HPV screening in this group, underscore need for awareness of Lynch status to avoid false negs. sciencedirect.com/science/articl…

Happy to conclude the annual #ASCP2024 meeting by presenting our topic on aggressive cutaneous lymphoma with my wonderful colleague UVA Pathology Dr Linglei Ma.

Get all your pathology questions answered by our AMAZING panelists. We look forward to seeing you, Sign Up Today!! Sign up here: us02web.zoom.us/meeting/regist… Submit Questions Here: forms.gle/idYv1dbmNa19CH…

From 🔬 to 🎾! We started free group tennis lessons this week courtesy of UVA Health Hoos Wellness program. Let’s just say we are US Open bound… UVA Pathology Nouran Sinada Anna Vi Jones Aleksander Luniewski #pathology #residency #wellness #uva #pathmatch25 #path2path #path

Tweeples, can you point me to any good online resources that teach gross pathology? You can include people, accounts, etc on any platform. I a giving a talk at AAPA annual conference for Pathologists' Assistants and would like to give them a few recommendations. Thank you!

SOX17 - helpful in distinguishing a subset of Mesonephric-like CAs of the Mullerian tract (most are SOX17 negative/focal) from non-mucinous Mullerian CAs (SOX17 positive). 🔬 Histopathology International Society of Gynecologic Pathologists Brooke E. Howitt Brigham and Women's Pathology Stanford Pathology #gynpath onlinelibrary.wiley.com/doi/epdf/10.11…

Claudin 18.2 immunohistochemistry is new for gastric and esophageal adenocarcinomas. Benign gastric mucosa is the internal positive control. 2+-3+ membrane staining in ≥75% of tumor cells is the cutoff for use of anti-CLDN18.2 (zolbetuximab). #UMiamiPath PMID: 39098518.