When writing a research proposal, consider asking yourself some questions: -why is this area important? -what is the unmet need or unanswered question? -how will my research address that? -why is this the best approach? -what expertise will I leverage? -what is my backup plan?

Photographers say the best camera is the one you have with you. Same for tests; the best test is the one you can take and get results from today. This essay explains why asymptomatic spread makes it important to expand rapid testing Michael Mina statnews.com/2021/01/23/asy…

Our article describing a modular de novo biosensor system is now online as an Accelerated Article Preview. We make sensors to detect COVID viral proteins! #Bioluminescence #De novo protein #Biosensor nature.com/articles/s4158… ipd.uw.edu/2021/01/covid-…

Scientists Institute for Protein Design have created light-emitting biosensors that quickly detect coronavirus proteins & antibodies. The sensors glow when they find & bind their targets. Reported nature Next goal is ensuring they are reliable in diagnostic testing bit.ly/2MD2oi3

De novo design of modular and tunable protein biosensors nature.com/articles/s4158… | nature New sensors detect coronavirus proteins and antibodies ipd.uw.edu/2021/01/covid-… | UW Medicine

And “When historians look back, they will see that science and scientists rose to the moment, but politics failed almost everywhere, and made it much worse... they will say that in the short run, politics inflicted huge damage on society, and cost lives.”

Protein-based biosensors illuminate a future of cheap, accessible COVID-19 testing dailyuw.com/news/article_4… via The Daily of the University of Washington

Happy to announce that our work on broadly protective nanoparticle-based influenza vaccines has been published in Nature! rdcu.be/chpnW Supraseasonal flu vaccine = protects against seasonal flu even when that year's strain prediction is off, plus some more 1/9

“What I’d encourage everyone to think about is, now that we can design proteins with intent, what is possible?” – David Baker, director Institute for Protein Design bit.ly/3dpMEJ4 UW Biochemistry

Accurate prediction of protein structures and interactions using a 3-track network biorxiv.org/content/10.110…

Design of protein binding proteins from target structure alone | nature Our approach now enables targeted design of binders to sites of interest on a wide variety of proteins for therapeutic and diagnostic applications. #proteindesign nature.com/articles/s4158…

What a birthday (April 28) treat! Andy H.W. Yeh and my paper on a designed biosensor to detect COVID-19 antibodies is now online! rdcu.be/cMjL3 Ian Haydon and I also wrote a Nature Bioengineering community blog post about this paper as well: go.nature.com/3MERJNw

ProteinMPNN paper: science.org/doi/10.1126/sc… Github: github.com/dauparas/Prote… Colab notebook: github.com/dauparas/Prote… HuggingFace notebook: huggingface.co/spaces/simondu… Hallucinating symmetric protein assemblies paper: science.org/doi/10.1126/sc… Thanks to all collaborators!

We made #AlphaFold dream of new protein assemblies, used #ProteinMPNN to bring it back to reality, and the results were stunning! (1/5) science.org/doi/10.1126/sc…

01. Today we report the computational design of highly efficient enzymes. Lab testing confirms that these novel luciferases can recognize specific synthetic substrates and efficiently catalyze the emission of light. nature.com/articles/s4158…

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