Metabolic dysfunction in severe mental illness: updates on prevalence, aetiology and treatment options BJPsych Journals Hub for Metabolic Psychiatry bit.ly/4ekzT01

PhD confirmation seminar done Been a big few weeks but now awaiting examiners feedback and input 2025 is going to be a big year Thank you always to my supervisors Michelle Minehan, Andrew McKune 🇿🇦 🇦🇺 and Stephan for your support so far. University of Canberra UCRISE

🚨Discovery of a New Ketone Body Metabolite that Suppresses Appetite 1/5)🧵This thread will review new data, and suggest one reason why some people might lose more weight on #ketodiet than others The research, publish in Cell, documents the discovery of a byproduct

Consensus on the key characteristics of metabolism disruptors | Nature Reviews Endocrinology nature.com/articles/s4157…

Are people with epilepsy more likely to have a mental health condition? Yes Which one? Essentially all of them, including anxiety, depression, bipolar disorder, schizophrenia, OCD, PTSD, eating disorders, substance use disorders, ADHD, and autism. jamanetwork.com/journals/jaman…

This meta-analysis finds that exercise is likely to increase resting brain-derived neurotrophic factor concentration in older adults and the most effective interventions have a frequency of 3–4 sessions per week, at moderate to vigorous intensity and over at least 12 weeks.

Findings from this one suggest that mitochondrial health, as assessed by higher in vivo muscle oxidative capacity, is associated with preserved brain structure up to over a decade, particularly in areas important for cognition, motor function, and sensorimotor integration.

Important recent paper for Metabolic Psychiatry in Nature - Scientific Reports 162,253 case and control patients: "This study showed a significant association between GLP-1 RA treatment and an 98% increased risk of any psychiatric disorders. Notably, patients on GLP-1 RAs

🤯Nothing Short of Stunning! In the brain 🧠, immune cells called microglia and 'suck up' harmful protein aggregates AND 'donate' healthy mitochondria through "bidirectional tunneling nanotubes" -- literal microscopic tunnels. I'm constantly in AWE of biology. #StayCurious

Ketosis is an anti-seizure intervention with 13 RCTs. Bipolar is often treated with anti-seizure medications. I think there are plausible and testable mechanistic links, which I propose in detail here: nature.com/articles/s4138…

Cellular crosstalk in skeletal muscle? A surprising role for mast cells? Histamine as a signal transducer during exercise? This was an amazing ride during my time TeamDerave, now published in Cell Metabolism (1/11) UGent Geneeskunde & Gezondheidswetenschappen, FWO sciencedirect.com/science/articl…

New project from our team: Survey of Canberra Long-distance Runners Use of Supplements And Knowledge of Australian Native Plants For more details and to complete the questionnaire please visit: lnkd.in/gNPNmUNE FFNR Laboratory UCRISE University of Canberra

🌟Upcoming Event!🌟 We are delighted to announce that we will be hosting our inaugural special lecture with guest speaker, Benjamin Perry on 5th March, 4-5pm! Please use the links below to register 👇 Online: lnkd.in/eRenVH2A In-person: lnkd.in/erFUuhzH

Solid study examining the effects of nutritional ketosis on mood, symptoms, metabolic, and brain metabolites

This month's issue of Biological Psychiatry is focused entirely on Metabolic Psychiatry! Slowly but surely, the psychiatric and neuroscience research communities are recognizing the profound connections between metabolism and mental health. biologicalpsychiatrycnni.org/current

Depression is not just a brain condition—it is a systemic condition affecting brain and body. This research finds adults with depression have more physical health conditions at baseline and accrue additional physical health conditions at a faster rate. journals.plos.org/plosmedicine/a…

I'm glad to see Ralph DeFronzo getting some attention recently. In the realm of insulin resistance, he's a legend. Let's look at a bit of some of his more novel, yet overlooked, work. Whether intentional or not, his work provides robust support for the carbohydrate-insulin

On non-lift days: Moving around > sitting around Or, to be more controversial: Active recovery > passive recovery Positive effects of AE on cardiovascular health/fitness, even if effects on soreness/performance are neutral. Your heart, aorta, & ANS will thank you.

Ketones exhibit robust effects in restabilizing brain networks. 🧵1/9