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🔔 New manuscript alert 🔔 The first effort at surveillance for OAS on a national scale “Surveillance for Opioid-Associated Amnestic Syndrome in Canada, 2010-2022” medRxiv medrxiv.org/content/10.110… (🔓) 1/🧵

From Sweden 🇸🇪: new open access systematic review of meds assoc w cog impairment, incl opioids (incl ref to OAS) Lund University link.springer.com/content/pdf/10… (🔓)

New publication: CHANTER is an under-recognized syndrome of multifocal cerebral edema after opioid ingestion. It's important to recognize: diffusion restriction and edema are reversible and outcomes are promising! Free copy: tinyurl.com/2s468pz4 Dan Harrison, MD Brigham and Women’s Neurocritical Care

🔍 Worthwhile read on OUD and dementia in medRxiv out of 🇬🇧🇺🇸🇳🇴 “We found genetic evidence to support the hypothesis that OUD causally impacts dementia risk. The μ-opioid receptor (OPRM1) was implicated as a key biological pathway.” 🧠 medrxiv.org/content/10.110… (🔓)

Brought to my attention that credit goes Francis Deng, MD for the original slides cited in the link - thanks Radiopaedia.org for the correction

What does the hippocampus look like in opioid-induced amnesia? youtube.com/shorts/sq3SOiv…

Most neuroprotection trials fail. Mostly related to monotherapy for a multifaceted pathophysiology Read more about it Kofke WA, Miano TA. Failed Neuroprotection Trials: An Evaluation of Complexity and Clinical Trial Design. Anesthesiology. 2025 Jan 14. pubmed.ncbi.nlm.nih.gov/39813404/

Could opioid receptors (OR) be a 🎯 of Alzheimer’s (AD) treatment? A new study in a mouse model 🐁 of AD proposes delta OR agonist 🤔 alzres.biomedcentral.com/articles/10.11… 🔓(open access)

big day for whoever makes these things

CHANTER spectrum syndrome in Am J Emerg Med pubmed.ncbi.nlm.nih.gov/39884939/ Andrew Kofke Joshua Madden, MD

Important study from U of Florida: By 8 y follow-up, ⬆️-dose opioid use (≥ 90 MME daily) was assoc w > memory decline and dementia probability (latter 16.8% ⬆️er vs patients w ⬇️-dose or no opioid use) Almut Winterstein UF McKnight Brain Institute Alzheimer's & Dementia Journals alz-journals.onlinelibrary.wiley.com/doi/10.1002/al… (🔓)

Another CHANTER spectrum abstract to be presented American Academy of Neurology National Meeting 🧠 Interesting strategy in CHANTER to maintain/wean fentanyl to prevent withdrawal symptoms, noted case w signif recovery 📈

Interesting mention of OAS in Psychiatrist.com article on “Mitigation of Anxiety, Agitation, and Pain in Critically Ill Patients” Stanford Medicine psychiatrist.com/pcc/mitigation… (🔓) 1/2

The Oxford Textbook of Neurocritical Care 2ndedition is available for pre-order website:global.oup.com/academic/produ….

⭐️ What is the most likely diagnosis in this 45 y/o M found down with history of polysubstance abuse? #Neurology #Medicine #radres #Neurosurgery #futureradres #radres #FOAMed #MRI Albany Med Radiology Residency The American Society of Neuroradiology

Trump signed an Executive Order directing the Corporation for Public Broadcasting to "cease federal funding for NPR and PBS." Here's what Mr. Rogers told Congress when Richard Nixon tried gutting public broadcasting 56 years ago.

Uk biobank -200,000 subjects opioid use associated with dementia, mri changes, and lower cognitive test scores alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

📣 New article alert! 📣 Great to work with Feng Sha Andrew Kofke et al exploring assoc betw regular opioid exposure, MRI brain volumetrics, and dementia outcomes 🧠 Alzheimer's & Dementia Journals 🔓 1/brief 🧵 alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

We know about acute impacts of opioid misuse — incl opioid-associated amnestic syndrome and CHANTER — on the brain BUT Regular prescription opioid use may additionally have a longer-term impact on brain structure and function 3/end

The 2nd edition of the Oxford textbook of Neurocritical Care is now available. With grateful thanks to the co-editors Giuseppe Citerio Andrew Kofke & Geert Meyfroidt and all contributors. global.oup.com/academic/produ… SNACC QSNCCU Oxford Academic OUP Medicine 🄽🄰🄲🄲🅂