Why hasn’t AOPA | Aircraft Owners and Pilots Association come out against calls, made from the President-elect no less, to shoot down suspected drones that are likely to be piloted gen av? As a member I expect that. It’s been over 24 hrs.

Congratulations to pediatric neurosurgeon Cameron Sadegh, M.D., Ph.D., recipient of the 2024 Innovator Award. This award will support Dr. Sadegh's study, titled "Utilizing neurosurgical specimens to study intraventricular hemorrhage and the feasibility of targeted gene therapy."

We lost a true pioneer in the field of neuroscience and neuropharmacology, Dr. Floyd Bloom. Words can hardly capture the enormity of his contributions. His work was essential to our understanding of how neurotransmission works and how it influences mental disorders. Floyd’s

Shake 'N Bake

Lower slow wave sleep and rapid eye-movement sleep are associated with brain atrophy of AD-vulnerable regions biorxiv.org/cgi/content/sh… #biorxiv_neursci

📣 As promised, here is our protocol paper on chemotagging! This new technique combines calcium imaging with chemogenetics to identify cell types in commonly used Miniscope recordings & can be used to tag ANY CELL TYPE! Read about the technique here: biorxiv.org/content/10.110…

This is amazing! It shows that Ambien (zolpidem) does induce sleep but also puts the 🔵LC down, too. Pahsic activity in LC is important to clear the brain of toxins. "Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep: Cell cell.com/cell/fulltext/…

Excellent work of Brandon Toth and Christian Burgessand. It is intriguing to see how nature developed redundancy with these monoaminergic systems in the regulation of brain states. jneurosci.org/content/early/…

Pretty sure one of those folks down there right now is Brandon j. Harvey (EEG Salad)

A ventral pallidum-locus coeruleus-lateral hypothalamus pathway modulates brain arousal in freely behaving and isoflurane-anesthetized male mice nature.com/articles/s4146…

Allan Rechtschaffen was the one who said the quote about evolution’s biggest mistake. ;-) Enjoyable episode as always, though!

Nowhere in Texas or Florida is open and accessible to all. Puerto Rico, or maybe somewhere in NM if you want to save $$$. Not Texas as an alternative to Florida. Not going to ASCS.

Online now: Molecular mechanisms mediating engram ensemble retrievability state in mice dlvr.it/TNz8Rr

International recommendations for sleep and circadian research in aging and Alzheimer's disease: A Delphi consensus study alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

Happy Halloween from (left to right) Victory Monday Dan Campbell 🏈, Minion 🍌, ghost of Emily (get well soon! 🤧), and Reds baseball player ⚾️.

Excellent review article by Dr. Michael Grandner that finishes up a few thoughts that I had about A-β but never was able to close the loop on. journals.sagepub.com/doi/10.1177/13…

The brain’s wake-to-sleep transition follows bifurcation dynamics with a distinct tipping point preceded by a critical slowing down Nir Grossman Junheng Li Interventional Systems Neuroscience UK Dementia Research Institute nature.com/articles/s4159…

The APOE4 allele, present in >20% of the population, is a significant risk marker for #Alzheimers. What if we could flip it to the protective APOE2 allele? Encouraging results in the experimental model nature.com/articles/s4159… nature.com/articles/s4159…

Y’all might be seeing the northern lights tonight but sorry to disappoint, much of #Sfn2025 will be rainy and cool. Good for us Californians! Not so great for visitors.

Characterization of locus coeruleus neuronal properties with aging in two mouse models of tauopathy journals.sagepub.com/doi/10.1177/13…