Just learned the PDB file format was built for 80-column punch cards, how is comp bio still so reliant on it...

The room was packed! 🧬💾 Huge thanks to everyone who joined and made the second edition of In Silico such a success - it exceeded all our expectations! Thanks to all the speakers, and Barney Hill & David Miller! See you soon! 🦸‍♂️

Thanks for the shoutout YC - we’re building the future of programmable biology. Welcome to the era of vibe drug design !

Building a computational biology pipeline but don’t know where to start? Meet Amina... V2 Research, design and iterate on your next blockbuster therapeutic - no setup, no coding, and zero computational overhead !!

Shared models in drug discovery: “If we combine our data, we both train smarter models.” But if... Pharma A works on drug A Pharma B works on drug B Pharma A later enters B’s therapeutic space → gets B’s learnings for free. Does federated learning even make sense? are any

I keep saying “drug discovery” but most of my audience does not understand what this means. Here’s a thread I worked on over the past week trying to distil down drug discovery - and why it matters in the age of AI. OPEN THE THREAD 🧵

Jumped on the trend and added the illustrated viewer Thanks Steven Yu

🌍 The biggest decentralized science experiment of 2025 is starting now! The protein design competition returns: we’re inviting scientists, engineers, and hackers from around the world to help design new proteins capable of neutralizing the Nipah virus, a pathogen with up to 75%

Alright who's gonna compare OF3 to boltz-2 and boltzgen?

1/ 🚨Today history in AI 💻+ biology 🧬was made! CZI led by Mark Zuckerberg + Priscilla Chan who've admirably committed tens of billions (and the entirety of their wealth to CZI) has acquired Lux family co Evolutionary Scale––just 2yrs after it's founding at a great multiple...

Excited to announce the release of our open-source protein family language model, ProFam-1, designed to generate functional protein variants and predict fitness using in-context example sequences. 1/n

Going Founder Mode On Cancer centuryofbio.com/p/sid Sid Sijbrandij is a generational founder. He founded and led GitLab, one of the largest remote companies in the world, from idea-stage startup to NASDAQ-listed software giant. But in 2022, a six centimeter mass growing from

I just left a $3B startups office in London who moved here a month ago I’m so bullish. > Vercel’s recent meet up that had people queuing round the block > OpenClaw🦞 and OpenAI event at Imperial College London with 900 students >We’ve had Decagon, Clay, Rogo all open London

Excited to share yet another case study on using BAGEL 🥯👨🏻‍🍳 for protein design – this time, we are miniaturizing enzymes! 🧬✂️ Paper 📄 doi.org/10.64898/2026.… Data 💾 zenodo.org/records/188541… Code 👨‍💻 github.com/softnanolab/ba…

We're also releasing a massive self-distillation set, a key ingredient in training AF3, comprising millions of diverse MSAs and structures. We estimate its cost to near $20M, representing perhaps the largest compute investment by an academic effort for a biological dataset. 6/9