The September issue is live nature.com/nbt/volumes/42… Our cover shows cellular mRNA modified by m⁶A, which is depicted as a gemstone. Marayati et al. develop GEMS, a genetically encoded m⁶A sensor that can report changes in m⁶A in living cells go.nature.com/41N2h67

I’m so thrilled to share my first first-author pre-print! 💪🎉🥳 This was an amazing collaborative work from Nitika Taneja, Andrés Aguilera and @lugerlab! How do #chromatinremodelers, #Rloops and mutations in #cancer correlate? A small 🧵below for you! biorxiv.org/content/10.110…

Happy to see this published!

Curious about the seemingly contradictory functions of m6A in R-loops? Check out this comment by @a_abakir & Alexey Ruzov out in Nature Genetics where they propose a new model for a dual function of m6A in R-loop regulation. nature.com/articles/s4158…

Abdulkadir Abakir, PhD Nature Genetics Reik Lab Altos Labs Alexey Ruzov The dual function of m6A is really instersting！And not only existing in R-loop regulation, but also in gene expression regulation！

very nice comments

The SharedIt link for our (with Abdulkadir Abakir, PhD) comment in Nature Genetics rdcu.be/dUbLY We propose that in different contexts, m6A may either directly prevent R-loop accumulation or stabilize R-loops via the formation of RNA abasic sites. nature.com/articles/s4158…

Nice comment in Nature Genetics about the role of m6A in R-loop dynamics. Just one little detail: you refer to FLC (FLOWERING LOCUS C) as FLORAL REPRESSOR LOCUS. Plant people are always surprised that we´re still interested in it. There´s still work to do😜 nature.com/articles/s4158…

N1-methyladenosine (#m1A) is abundant and dynamic in the mRNAs of #dinoflagellates, and could have an important role in post-transcriptional #generegulation. Paper by Hao Chen and co-workers: embopress.org/doi/full/10.10… and the highlight by JaffreyLab: embopress.org/doi/full/10.10…

The very early evolution of biological complexity dlvr.it/TDh5K8

Does 6mA exist in eukaryotic DNA? This is our take on this dispute: yes it does, and can be very abundant, but mostly correlates with presence of the MT-A70 writer AMT1. Then, 6mA is associated with transcriptionally-permissive chromatin (H3K4me3) 1/6: biorxiv.org/content/10.110…

Achievement Unlocked! huihui an, our 1st PhD student’s 1st 1st-author paper! Out now in Molecular Cell 🧵 We identify the 1st m6Am Reader and uncover a novel and unexpected mechanistic role for this abundant yet enigmatic mRNA modification. (1) cell.com/molecular-cell…

Tuscan countryside, Italian food and… chromatin modifications! Thats as good as it gets. Greatly looking forward to this:

Now in print! A model for a dual function of N6-methyladenosine in R-loop regulation | Nature Genetics ⁦Nature Genetics⁩ nature.com/articles/s4158…

exciting future for m6A in #Rloop great perspective Abdulkadir & Alexey Ruzov so much yet to learn 🤓

Excited to share our latest research out now in Molecular Cell. DNA supercoiling creates topological issues that affect nuclear DNA transactions, with cells using topoisomerases to resolve these constraints. (1/7) cell.com/molecular-cell…

Analyzing whole genome DNA methylation data? Our new method MethyLasso is out in NAR! It can help you identify regions with low or partial methylation (LMR, UMR, DMV, PMD, PMD) or differentially methylated regions (DMR) and was benchmarked against others doi.org/10.1093/nar/gk…

Congrats to our colleague Qin Peng on the development of a m6A live-cell imaging method. Glad to have helped out on this work. science.org/doi/10.1126/sc…

Gene regulation involves thousands of proteins that bind DNA, yet comprehensively mapping these is challenging. Our paper in Nature Genetics describes ChIP-DIP, a method for genome-wide mapping of hundreds of DNA-protein interactions in a single experiment. nature.com/articles/s4158…

Pleased to share our latest work: Chimeric cofactors enable methyltransferase-catalyzed prenylation: Chem cell.com/chem/fulltext/… Kudos to @EnzymeNicoCorn, Arne Hoffmann, Pulak Ghosh and x-less coathors 👏🤩👍