Alexei Maklakov (@alexeimaklakov) 's Twitter Profile
Alexei Maklakov

@alexeimaklakov

Biology of Ageing and Life History Evolution

ID: 2608528051

linkhttps://alexeimaklakov.com/ calendar_today06-07-2014 23:12:57

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Alexei Maklakov (@alexeimaklakov) 's Twitter Profile Photo

Short experimental heatwaves have sublethal impacts on male reproduction in a model insect journals.biologists.com/jeb/article/do…

Agingdoc⭐David Barzilai🔔MD PhD MS MBA DipABLM🩺 (@agingdoc1) 's Twitter Profile Photo

Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer’s disease 👉 “Our results demonstrate that fasting is a critical component of the benefits of CR on AD, suggesting that fasting alone or fasting-mimicking diets might help to

Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer’s disease

👉 “Our results demonstrate that fasting is a critical component of the benefits of CR on AD, suggesting that fasting alone or fasting-mimicking diets might help to
Tomás Schmauck-Medina (@tschmauck) 's Twitter Profile Photo

First, really cool work by Ben Shenhar Sara Hägg Uri Alon and others: using twin records, they show that once you filter out confounders like extrinsic mortality, heritability explains ~50% of human lifespan in that population. biorxiv.org/content/10.110…

Tomás Schmauck-Medina (@tschmauck) 's Twitter Profile Photo

Secondly, Christian David Meyer Björn Schumacher used transcriptomic clocks in C. elegans to show that different neuron types age at different rates, with ciliated sensory neurons aging the fastest. researchsquare.com/article/rs-436…

Björn Schumacher (@schumacherbj) 's Twitter Profile Photo

🔥🔥🔥our Nature Aging Perspective Aging by the clock and yet without a program. Together with David Meyer and Alexei Maklakov we demonstrate how the aging process is driven by molecular damage and how the selection shadow lets us age rdcu.be/eG1N7

Alexei Maklakov (@alexeimaklakov) 's Twitter Profile Photo

We argue that selection shadow - decline in the force of selection after the onset of reproduction - is sufficient to explain why damage accumulates with age. 'Aging clocks' measure damage accumulation, they neither require nor support any kind of 'program'-based explanation.

Agingdoc⭐David Barzilai🔔MD PhD MS MBA DipABLM🩺 (@agingdoc1) 's Twitter Profile Photo

Early menarche and childbirth accelerate aging-related outcomes and age-related diseases: Evidence for antagonistic pleiotropy in humans "Our study highlights the complex relationship between genetic legacies and modern diseases, emphasizing the need for gender-sensitive

Early menarche and childbirth accelerate aging-related outcomes and age-related diseases: Evidence for antagonistic pleiotropy in humans

"Our study highlights the complex relationship between genetic legacies and modern diseases, emphasizing the need for gender-sensitive
Agingdoc⭐David Barzilai🔔MD PhD MS MBA DipABLM🩺 (@agingdoc1) 's Twitter Profile Photo

Avian Lifespan Network Reveals Shared Mechanisms and New Key Players in Animal Longevity "This lifespan network not only provides evidence for shared mechanisms of lifespan regulation across different organisms but also enables the identification of new candidates for studying

Avian Lifespan Network Reveals Shared Mechanisms and New Key Players in Animal Longevity

"This lifespan network not only provides evidence for shared mechanisms of lifespan regulation across different organisms but also enables the identification of new candidates for studying
Itai Yanai (@itaiyanai) 's Twitter Profile Photo

Interested in cellular plasticity? Come to my live virtual talk on Monday! Free register here: cassyni.com/events/ApfsK82…

Interested in cellular plasticity? Come to my live virtual talk on Monday! Free register here: cassyni.com/events/ApfsK82…
Anne Carpenter, PhD (@drannecarpenter) 's Twitter Profile Photo

15 years in the making, we confirmed that mitochondria -the powerhouse of the cell- have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery...🧵

15 years in the making, we confirmed that mitochondria -the powerhouse of the cell- have an unusual localization in patients who experience psychosis (including schizophrenia and bipolar disorders). You’ll never guess what kind of patient cells we used to make this discovery...🧵
Richard Dawkins (@richarddawkins) 's Twitter Profile Photo

Entangled Life by Merlin Sheldrake is one of the best works of scientific literature I have ever read: intelligent (a scientist can be good at philosophy), informative (I learned so much), inspiring (almost every sentence made me pause for thought), beautifully written (this

Entangled Life by <a href="/MerlinSheldrake/">Merlin Sheldrake</a> is one of the best works of scientific literature I have ever read: intelligent (a scientist can be good at philosophy), informative (I learned so much), inspiring (almost every sentence made me pause for thought), beautifully written (this
Eric Topol (@erictopol) 's Twitter Profile Photo

Discovery of a way to regenerate the thymus gland through mesenchymal cells, with implications for enhancing the T cell immune response in multiple medical conditions and with aging nature.com/articles/s4158… nature.com/articles/s4158…

Discovery of a way to regenerate the thymus gland through mesenchymal cells, with implications for enhancing the T cell immune response in multiple medical conditions and with aging
nature.com/articles/s4158…
nature.com/articles/s4158…
Alexei Maklakov (@alexeimaklakov) 's Twitter Profile Photo

Fast females, slow males: accelerated ageing and reproductive senescence in Drosophila melanogaster females across diverse social environments academic.oup.com/evlett/article…

Ho Ko (@shibadaddo) 's Twitter Profile Photo

Delighted to share the latest paper from our team in Cell Metabolism (cell.com/cell-metabolis…), which has been selected as the cover article for the upcoming December 2025 issue. In this study, we demonstrate that GLP-1R agonism (using the drug exenatide) confers body-wide

Delighted to share the latest paper from our team in Cell Metabolism (cell.com/cell-metabolis…), which has been selected as the cover article for the upcoming December 2025 issue.

In this study, we demonstrate that GLP-1R agonism (using the drug exenatide) confers body-wide