🔥The 9th Round of Easy Loan, Earn $40 Reward is in progress❗️ ⏰ Promotion Period: January 15th - Feburary 15th, 2025 👉 Register now and check more details at gate.io/campaigns/358

6 novel monoallelic PTPN2 mutations in pediatric lupus and Evans syndrome that cause T cell hyperproliferation and high inflammatory cytokines Journal of Experimental Medicine doi.org/10.1084/jem.20… @MACattackLab comment doi.org/10.1084/jem.20… Belot Alexandre @FRLab1 #Mathieu

Haploinsufficiency in PTPN2 leads to early-onset systemic #autoimmunity from Evans syndrome to #lupus, say Marie Jeanpierre (@JEANPIERRMarie), Jade Cognard (Jade Cognard), Frédéric Rieux-Laucat @FRLab1, Belot Alexandre, Anne-Laure Mathieu & colleagues hubs.la/Q02HvkMP0

PTPN2 deficiency: Amping up JAK/STAT. Joshua Tobin and Megan Cooper @MACattackLab Test Account discuss study from Marie Jeanpierre, Jade Cognard, @FRLab1, Belot Alexandre, Mathieu and colleagues (hubs.la/Q02HrXdq0): hubs.la/Q02HrFLB0

Findings from @JEANPIERRMarie, Jade Cognard, @FRLab1, Belot Alexandre et al. suggest that PTPN2 along with SOCS1 haploinsufficiency constitute a new group of monogenic autoimmune diseases that can benefit from targeted therapy. hubs.la/Q02Hvg8z0 #lupus #autoimmunity

Incredible discovery. Also very informative for users of TNFa blockers!

Fantastic findings, very elegant! Well done Petter and Co. 👏👏

The upcoming rheumatopedies meeting coming soon: great speakers and exciting research from masters , PhD student and researchers with guest speakers Filomeen Haerynck & Dan Kastner !

Proud of you Jade Jade Cognard for winning first prize for your basic/translational research abstract on PTPN2-HA! 🎉 @FRLab1 LYACTS-CIRI Congrats to all presenters for an excellent #PRES2024 congress! See U next year

Delighted to host Elena Hsieh for a great talk on how to explore renal biopsies of #lupusnephritis with multi-omics including spatial transcriptomics. CIRI Lyon LYACTS-CIRI HCL | Recherche en santé

Félicitations ML ! Ce n'est qu'une étape, le meilleur à venir ! bravo 👏👏👏 c'est bien mérité

🌟Join us for our next Tuesday Lunch with RITA webinar on October 1! Topic: "Histiocytosis and Inflammation: How I Manage H Syndrome." 🗓️ 12:00 - 13:00 CEST Panelists: Dr. Maurine Jouret & Dr. Julien Haroche Chair: Dr. Belot Alexandre 🔗 Register: register.gotowebinar.com/register/34420…

Une chance pour l'HFME et les enfants malades pour le bien-être de nos jeunes patients et la promotion de leur activité physique. HCL | Recherche en santé, HCL - Hospices Civils de Lyon. Un grand merci @OLfondation, Maelle & Christophe et félicitations aux nouveaux venus au CA Wendie Renard Govou Sidney !

🗣️Excited to share our paper defining a standard dataset for cSLE registry research! 🩺Our team developed a core dataset to harmonize cSLE data collection and promote international collaboration to advance cSLE research! ard.bmj.com/content/annrhe… Eve smith Belot Alexandre

Part of the fascinating world of JAK-STATopathies!

Systemic lupus pathophysiology through the lens of genetics - By Quentin Delcros (Interne en Médecine Interne, Paris, France) #genetic #lupus #InternistAcademy 2024

📢Reminder to register for the next Lunch with RITA webinar! 🗓️ 5 Nov 2024 ⏰ 12:00 CET 💬 Topic: Granulomas in PID & Immune Dysregulation 🎙️ Speakers: Dr. Benjamin Fournier & Dr. Carine Wouters Don’t miss insights on key treatment strategies! 🔗Register: lnkd.in/edeD8ADC

‘Human Peoples’ is out Penguin Books A genetic journey through how migrations, admixture (among humans and with Neanderthals and Denisovans), and adaptations to environmental pressures (climate, nutrition, pathogens) shaped our physiology and health today. amazon.co.uk/Human-Peoples-…

With Filomeen Haerynck & Dan Kastner and many new / unpublished works from talented Post doc, phD student and seniors

IFNopathies: Des guidelines très utiles par une équipe pluridisciplinaire. Merci à tous !

Genetic clues explain why children develop a rare post-COVID condition. Vanessa Sancho-Shimizu and researchers from our Imperial Department of Infectious Disease and The Francis Crick Institute have uncovered genetic variants which help explain why some children developed MIS-C after having COVID-19. imperial.ac.uk/news/258534/ge…