"Design, synthesis and in vitro evaluation of bivalent chemical probes targeting the tandem BD1/BD2 in BET proteins" (P18) DCF-SCI #NPCF13 #DCFSCI #epigenetics

The final version is out as advance article in an #OpenAccess #TransparentPeerReview format. EpigeneticMedChemLab Monica Viviano AlessandraFeoli Ciro Milite Alessandra Cipriano Sabrina Castellano

Huge congratulations to Giulia Iannelli for brilliantly defending her PhD thesis entitled “Design, synthesis, biological evaluation, and binding studies of small-molecule modulators of PRMTs”. Great job! At EpigeneticMedChemLab we are very proud of you!

Our work on deconstruction–reconstruction approach turning non-selective type I PRMT inhibitors into potent and selective PRMT4 inhibitors is now available (open access) in ACS Publications Bio & Med Chem Content JMC (asap). Thanks to all coauthors! EpigeneticMedChemLab   shorturl.at/bnuEZ

A very nice collaboration of ⁦EpigeneticMedChemLab⁩ with ⁦Alessio Ciulli⁩ and Panagis Filippakopoulos led to the identification of BET inhibitors with selectivity for the 1st bromodomain. Just accepted in ⁦ChemMedChem⁩. Congrats to all! …mistry-europe.onlinelibrary.wiley.com/doi/10.1002/cm…

Our Perspective on NADPH Oxidases, spanning from molecular mechanisms to current inhibitors has just been published on-line (open access) in J. Med. Chem. (ACS Publications Bio & Med Chem Content). Thanks to all the members of EpigeneticMedChemLab involved! pubs.acs.org/doi/10.1021/ac…

EpigeneticMedChemLab welcoming our guest, a visiting PhD student from Freiburg ! Nice to make your acquaintance, Maxi! Alessandra Cipriano Ciro Milite AlessandraFeoli Giuliana Sarno