Alberto J Espay (@albertoespay) 's Twitter Profile
Alberto J Espay

@albertoespay

#Neurology professor @uofcincy. I continue to try Bluesky since Nov 13, 2024 to foster a more collegial exchange of ideas. @albertoespay.bsky.social.

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linkhttp://CCBPStudy.com calendar_today06-10-2019 15:49:25

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APOE4 E4/E4 yields a 60% lifetime risk of #Alzheimers by age 85. E3/E3 does not affect risk. Why the difference? Although amyloid and tau PET look similar, there is a rapid and early Aβ42-to-amyloid conversion in E4/E4, depleting CSF Aβ42 levels. nature.com/articles/s4159…

APOE4 E4/E4 yields a 60% lifetime risk of #Alzheimers by age 85. E3/E3 does not affect risk. Why the difference?

Although amyloid and tau PET look similar, there is a rapid and early Aβ42-to-amyloid conversion in E4/E4, depleting CSF Aβ42 levels. 

nature.com/articles/s4159…