How does white blood cell inflammation contribute to blood vessel changes in the lung and heart failure? Dr. Andrew J. Bryant will be with us on 05/31 to answer this question based on his recent publication!

This Friday: Do not miss the exciting opportunity to #AskTheAuthor on (X): Highlighting: Vascular Biology in the Spotlight - 10.1161/ATVBAHA.123.320121, starting @ 9:00AM CST, please join in the discussion tomorrow! #ATVB_net, #DigitalStrategyTeam

#ATVBMeetTheAuthor ahajournals.org/doi/10.1161/AT…

0⃣1⃣ Andrew J. Bryant Can you briefly describe your research study and what is your main finding? ahajournals.org/doi/10.1161/AT…

0⃣2⃣ Andrew J. Bryant Could you please explain the STING pathway in vascular cells and how that is different than immune cells?

0⃣3⃣ Andrew J. Bryant The findings indicate that STING-associated type I IFN signaling plays a minor role in PH pathogenesis. How might the timing of type I IFN activation influence PH progression and stage-specific therapeutic interventions? Kanika Jain

0⃣4⃣ Andrew J. Bryant Your finding of the high STING expression in the muscular arteries in patients with pulmonary hypertension is interesting, what the primary cells?

0⃣5⃣ Andrew J. Bryant What are the next research steps to understand STING's role in preventing right-heart failure in end-stage PH, and how might this inform new therapies? Kanika Jain

0⃣6⃣ Andrew J. Bryant Can you please expand on your animal model and why you chose that? Which stage of the disease it is mimicking?

ATVB: An AHA Journal Andrew J. Bryant We actually observed STING is highly expressed in the endothelial layer of remodelled pulmonary vessels of group 3 PH patients. And STING knockdown can active BMPR2 signaling.

0⃣7⃣ Andrew J. Bryant How does STING's function in PH compare to its roles in lung fibrosis, cancer, and autoimmune conditions? Kanika Jain

0⃣8⃣ Andrew J. Bryant How do you think STING affects PDL-1 expression in hypoxia-induced PH?

0⃣9⃣ Andrew J. Bryant The effect of STING KO on VEGF production from monocytes is interesting, how? Do monocytes need to be in contact with ECs?

SEE YOU NEXT TIME!!

The common TMEM173 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice; great work from our collaborator Lei Jin! elifesciences.org/reviewed-prepr…

Ever wonder how smooth muscle and inflammatory cells act through a common mediator in causing pulmonary hypertension? STING may be the answer. JCI Insight - Opposing roles for myeloid and smooth muscle cell STING in pulmonary hypertension insight.jci.org/articles/view/…

Parsing the STING in pulmonary hypertension— Andrew J. Bryant & team FLORIDA report on opposing roles for STING in PH—a paradigm shifting mechanism suggesting we refocus on treatments that target cell-specific inflammatory activation: insight.jci.org/articles/view/…

"Opposing roles for myeloid and smooth muscle cell STING in pulmonary hypertension" by Andrew J. Bryant & team insight.jci.org/articles/view/…

JCI insight Andrew J. Bryant The findings you highlight from the Andrew J. Bryant team about STING's varying roles are truly fascinating! They propose a crucial shift in how we approach inflammation-driven diseases like pulmonary hypertension. Focusing on the cell-specific activity could lead to more effective

STING and PH? Check it out!