Axel Grothey
@agrothey
Passionate about justice & tolerance, teaching & educating oncologists, caring for cancer patients, learning from mistakes. Opinions and statements are my own.
ID: 24327965
14-03-2009 04:24:19
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PANDAS PRODIGE 44 BR-PDAC ➡️mFFX vs mFFX + caperads 50.4Gy ➡️No diff in R0 resection rate ➡️No diff in mOS 32.8 vs 30mths ➡️numerically longer locoregional recurrence rate in RT arm but not sig ‼️imp to note in those randomised how many get to adjuvant ~50% #ESMO2024 HPB Dublin
Another Low Dose IO trial from India 🇮🇳 CMC Vellore 🙂👍 Necesity is mother of all inventions. Our patients can not afford full dose IO so we have to modify the dose and it works 🙂👍
🔥of the press Neoadjuvant nivolumab and relatlimab in locally advanced MMR-deficient colon cancer: a phase 2 trial Nature Medicine 👇doi.org/10.1038/s41591… ESMO - Eur. Oncology #ESMOAmbassadors #ESMO24
#ESMO24 ESMO - Eur. Oncology Excellent discussion by Jenny Seligmann contextualizing IO in early stage #CRCsm NICHE-2 and NICHE-3 Myriam Chalabi & IMHOTEP 📌non-randomized datasets, robust and meaningful efficacy 📌higher pCR with more IO ✅is this data enough to change practice? YES ⛔️is
Nothing is 100% in life except the 3yr DFS of NICHE-2 study!@Amitmahipal79 Myriam Chalabi antony ruggeri Dr Joseph McCollom DO Ibrahim Halil SAHIN, MD Anup Kasi MD MPH Suneel Kamath MD Bassam Estfan
Sharlene Gill, MD, MPH, MBA, FASCO ESMO - Eur. Oncology Kimmie Ng, MD, MPH Alliance for Clinical Trials in Oncology OncoAlert OncologyEducation Median PFS wasn’t significant in phase II either
some thoughts… #ESMO2024 - the DFS data of NICHE2 are definitive! Neoadj / definitive IO should be SOC in dMMR CRC. Re ATOMIC… Hard to compete with 100% 3yr DFS. And… Where are the ATOMIC data? Way overdue! Frank Sinicrope, MD Myriam Chalabi OncoAlert