"Phenylephrine suppresses uterine contractions through cAMP signaling" nature.com/articles/s4159… #uterus #reproduction #contractions #muscle #labor #phenylephrine #pregnant #pregnancy

"Long-term spironolactone treatment reduces coronary TRPC expression, vasoconstriction, and atherosclerosis in metabolic syndrome pigs" link.springer.com/article/10.100… @AuthorZone #spironolactone #Atherosclerosis #vasospasm #coronary #artery #MetabolicSyndrome

A non-opioid small molecule drug was developed that is effective in reducing neuropathic pain. Acting intracellularly in neurons, the drug does not require intrathecal administration. doi.org/10.1073/pnas.1… #pain #chronicpain #opioids #OpioidCrisis #PainManagement #ionchannels

R125H, W240S, C386R, and V507I SLC4A11 mutations associated with corneal endothelial dystrophy affect the transporter function but not trafficking in PS120 cells (doi: 10.1016/j.exer.2018.12.003) authors.elsevier.com/c/1YFRS3ImqzhE1 #cornea

Catechol estrogens stimulate insulin secretion in pancreatic β-cells via activation of TRPA1 channel. J. Biol. Chem. jbc.RA118.005504. doi:10.1074/jbc.RA118.005504 jbc.org/content/early/…

The TRPC6 inhibitor, larixyl acetate, is effective in protecting against traumatic brain injury-induced systemic endothelial dysfunction jneuroinflammation.biomedcentral.com/track/pdf/10.1… #TBI #BrainInjury #endothelialdysfunction #vascularhealth #trpchannels #TRP_channels #diterpenes #larixdecidua #larches

#mdpimolecules Long-Term Diabetic Microenvironment Augments the Decay Rate of Capsaicin-Induced Currents in Mouse Dorsal Root Ganglion Neurons mdpi.com/1420-3049/24/4… Molecules MDPI

Long-Term Diabetic Microenvironment Augments the Decay Rate of Capsaicin-Induced Currents in Mouse Dorsal Root Ganglion Neurons. mdpi.com/1420-3049/24/4… #Diabetes #TRPV1 #peripheralneuropathy

#mdpicells TRPC Channels mdpi.com/si/25796 MDPI

"The defect in gut barrier function and dysbiosis in ACE2-/y-Akita mice can be favorably impacted by exogenous administration of myeloid angiogenic cells." ahajournals.org/doi/10.1161/CI…

"HIV-Nef protein transfer to endothelial cells requires Rac1 activation and leads to endothelial dysfunction implications for statin treatment in HIV patients" ahajournals.org/doi/full/10.11…

SARS-CoV-2 Infections and ACE2: Clinical Outcomes Linked With Increased Morbidity and Mortality in Individuals With Diabetes; doi.org/10.2337/dbi20-… #SARS_CoV_2 #Covid_19 #ace2 #diabetes #SARS #COVID19 #coronavirus #covid

SARS-CoV-2 Infections and ACE2: Clinical Outcomes Linked With Increased Morbidity and Mortality in Individuals With Diabetes diabetes.diabetesjournals.org/content/early/… #COVID19 #SARS #coronavirus #SARS_CoV_2 #diabetes

In this year of 2020, we mark the 25th Anniversary of TRPC channel discovery. We wrote a review that provides a historical overview of events leading to TRPC discovery. Abstract: mdpi.com/2073-4409/9/9/… PDF: mdpi.com/2073-4409/9/9/… #trp #trp_papers #Physiology #disease #TRPC

ACE2 (Angiotensin-Converting Enzyme 2) in Cardiopulmonary Diseases Ramifications for the Control of SARS-CoV-2. ahajournals.org/doi/full/10.11… #COVIDー19 #SARSCoV2

The Potential Role of Osteopontin and Furin in Worsening Disease Outcomes in COVID-19 Patients with Pre-Existing Diabetes mdpi.com/2073-4409/9/11… #COVID19 #coronavirus #SARSCoV2

"Capsaicin and TRPV1 Channels in the Cardiovascular System: The Role of Inflammation" mdpi.com/2073-4409/11/1… #capsaicin, #chili, #hotpeppers, #hotpepper, #chiles

Dihydroceramides Derived from Bacteroidetes Species Sensitize TRPV1 Channels mdpi.com/1422-0067/24/1…

Long-Term Treatment with Gadopentetic Acid or Gadodiamide Increases TRPC5 Expression and Decreases Adriamycin Nuclear Accumulation in Breast Cancer Cells mdpi.com/2073-4409/12/9…

Effects of TRPC1’s Lysines on Heteromeric TRPC5-TRPC1 Channel Function mdpi.com/3076534 #mdpicells via Cells MDPI MDPI TRP Channels trppapers