Exciting and impactful work from Taewan Kim, Soyeon Koo and the Lorenz lab & collaborators🌟🎉🎉🎉

Interesting bioRxiv from Lorenz & colleagues using in vivo CRISPR-Cas9 screen to identify p53-mediated apoptotic cell death as major contributor to dopamine neuron loss & uncovered a causal link of TNFa-NFκB signaling in limiting cell survival biorxiv.org/content/10.110…

Excited to share initial press release BlueRock Therapeutics on promising results of Phase 1 trial in 12 PD patients bit.ly/3JCKneG. A major milestone on a 20+ year journey. Amazing leadership by Viviane Tabar, Memorial Sloan Kettering Cancer Center & BlueRock Therapeutics (Stefan Irion, Mark Tomishima & many more).

Preprint led by Chao Zhang Nathalie Saurat Doron Betel on a strategy for measuring/manipulating cellular age bit.ly/3KIJ7XI. “RNAge” is used to track induced aging strategies in iPSC human neurons & to perform in silico screen for identifying novel aging & rejuvenation compounds

The GENtoniK paper is finally out in Nat Biotech! go.nature.com/3ROgdZf A chemical cocktail to drive maturation of neurons and other hPSC-derived cell types. Congrats to Emiliano, Andrew, @OberstPolina, Yana Zorina - a.k.a. NeuroBead, Arianna Baggiolini, Shuibing Chen Gabriele Ciceri and many others.

Excited to share that our paper on an epigenetic barrier setting timing of maturation in human neurons is finally out nature! go.nature.com/48dhO0V.

“Why human brain cells grow so slowly?” This is a video piece on our epigenetic barrier paper at @NatureVideoChannel on YouTube. youtube.com/watch?v=lIJkc6…

Cell Taewan Kim Lorenz Transient TNF-α inhibition overcomes a p53-dependent survival restriction in grafted dopamine neurons as a clinically relevant strategy to promote functional dopamine neuronal engraftment in Parkinson’s disease cell.com/cell/abstract/…

Amazing work from an outstanding scientist So Yeon Koo (that I greatly admired in the Studer lab)! Many Congrats on this well-deserved achievement.

Excellent thread from So Yeon Koo on the paper (and also her thesis work 😊). Congrats!

Now online! TNF-NF-κB-p53 axis restricts in vivo survival of hPSC-derived dopamine neurons dlvr.it/T8DDc6

How to trigger age-related features in hPSC neurons? In a CRISPR screen Nathalie Saurat identified neddylation inhibition as a tool to trigger hallmarks of aging in neurons and selective degeneration in AD or PD but not isogenic control neurons. @cellstemcell bit.ly/3XBxCsA