With the new academic year starting, and many people beginning fresh as graduate students, post-docs, or junior faculty, I have been thinking a lot about the core philosophies that govern my own perspectives on science. So I thought I would share. Welcome to The Tao of Cheese

Out nature! TDP-43 path induces crucial synaptic UNC13A mis-splicing and loss. ALS risk SNPs exacerbate this, worsening disease progression. We uncover the elusive UNC13A risk SNP mechanism, suggesting patients may do better if we correct UNC13A splicing. nature.com/articles/s4158…

Neuronal mitochondria transport Pink1 mRNA via synaptojanin 2 to support local mitophagy: cell.com/neuron/fulltex…

Congratulations Shi Jie for winning the Asian Scientist Magazine Lab Tech of the Year Mountain Mover Award! So well deserved, we're very happy for you 😊🎉🎉

Sad to learn that #Yale Prof. and colleague #SidneyAltman, 1989 Chemistry #Nobel recipient, has died. His publication on the #ribozyme action of #RNaseP was a milestone discovery in the now exploding field of #ncRNA. The photo shows him celebrating the news of his Nobel Prize.

I thought I had heard all the consciousness thought experiments but at #cshlNeuroAI Camilo Libedinsky told me a new one that literally kept me up last night. This is Camilo’s idea but I’ve taken some liberties with the details. Answer the polls in the order that you read them. 1/

Excellent summary of the replay thought experiment that I've used over the years to torment my students in NUS. Read the summary and vote! (Thanks Dr. Anna Schapiro for the succinct summary and poll :)

Camilo Camilo Libedinsky called this the "Sherry thought experiment" since grad school (the subject is usually called Sherry) and I'm proud to be the Sherry it is named after. 😅🤓

warm up with the following, just for fun (serious new ones coming this Fall). As Douglas Blackiston, Vaibhav Pai, Sherry Shiying Aw& I showed (journals.biologists.com/jeb/article/21…; pubmed.ncbi.nlm.nih.gov/22159581), functional eyes can be induced on many tissues (gut, tail) of a tadpole. During metamorphosis,

Tiny two-stem #riboswitch #aptamer RNAs in bacteria sense #sodium ions and regulate genes for Na+ homeostasis, #pH regulation, #osmotic stress, and even #ATP synthesis. Perhaps this is another molecular relic from the #RNAWorld. nature.com/articles/s4158…

20 years ago we published the first biochemical proofs that metabolite-sensing #riboswitch RNAs exist in bacteria. In an Trends in Biochemical Sciences TIBS review, we overview some of the discoveries made since, and speculate on what is yet to come. sciencedirect.com/science/articl…

Excited to announce registration for the 28th Annual Meeting of the The RNA Society is now open! This year’s meeting will be in-person Suntec Singapore Convention & Exhibition Center from May 30-June 4. Register today & see you in beautiful Singapore! #RNA23 www2.rnasociety.org

The replicability crisis is caused by a conflict between the goals of scientific progress and the personal career goals of individual scientists. In this thread, I propose a simple tweak to the publishing/funding system that could have large benefits to scientific progress (1/n)

Where transcription begins determines where it ends! Check out our latest study, published today in Cell. A huge tour de force, led by the extraordinary Carlos Alfonso-Gonzalez @extended_gene doi.org/10.1016/j.cell… 🧵1/10

Our lab is seeking a motivated postdoc to study how the brain resolves conflicts. Don't miss out! Apply by May 30th. Visit rezavallab.org to learn more and submit your application. #postdoc #postdocjobs #neuroscience #Drosophila

Happy to summarize this work with talented postdoc Roger Herikstad! When you initiate a movement after a sensory go cue, the time between the sensory signal and the movement onset is variable. This reaction time (RT) variability is observed even for well-practiced movements.(1/8)

Evaluating the transmission risk of amyloid beta peptide via ingestion biorxiv.org/content/10.110… The answer at the moment, thankfully, seems to be unlikely! Read more ⬆️

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Please join us in congratulating Dr. Katalin Karikó Katalin Kariko & Dr. Drew Weissman The Drew Weissman Lab on being awarded the The Nobel Prize for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19 #RNA #NobelPrize

Tom Baden Simen Bruøygard I see your zebrafish with an eye in its mouth, and I raise you 2 Xenopus tadpoles with a similar ectopic eye, made by modifying developmental bioelectricity (injection of K+ channel, by Sherry Shiying Aw when she was a student in my lab)! I have more photos somewhere.