Congratulations and best of luck!

The WntUK network emerged from discussions between UK delegates at recent international Wnt meetings in Japan and Spain. The founding committee is comprised of seven Wnt scientists from all corners of the UK. Read more about the founding committee members below 👇 1/n

New publication from the lab: Aged intestinal stem cells propagate inflammation. Congratulations to Maja Funk Maja Funk 🦋 - great collaboration with @odom_lab Mathias Heikenwälder Haas Lab Angelika Feldmann Oliver Stegle @dkfz Uni Heidelberg #ageing #organoids cell.com/developmental-…

Pleased to share our latest preprint identifying a GTPase cascade that modulates regional Wnt signalling in the intestine: biorxiv.org/content/10.110…

exciting news for patients with macular edema!!! Our Frizzled4 Wnt agonist had a positive Ph1/2b trial! eyebiotech.com/eyebio-announc…

The origin and evolution of Wnt signalling go.nature.com/3I3R887 #Review by Michaela Holzem, Michael Boutros & Thomas W. Holstein Thomas W Holstein Boutroslab Uni Heidelberg @COSHeidelberg

It was a great pleasure to work on this exciting topic! Please check out my new Review article on The origin and evolution of Wnt signalling! go.nature.com/3I3R887 #Review by Michaela Holzem, Michael Boutros & Thomas W. Holstein Thomas W Holstein Boutroslab

Incredible work by our collaborators Donnelly Centre finally out in nature! Please read and RT this important contribution to the TPD/TPS field and congrats to Juline Poirson, Mikko Taipale and the team! 🤗

It's a beautiful day at Niagara-on-the-Lake! 🌞 Donnelly Centre faculty, trainees and staff are at Queen's Landing Hotel for our annual retreat. #DonnellyRetreat2024 #UofT

🔦Preview of Kschonsak et al.: Get your receptors in a knot with new Wnt signaling agonists by Lucie Wolf and Stephane Angers at University of Toronto dlvr.it/T8YPWP

Congratulations to our 2024 Research Excellence Award Winners! 🥳 Postdoctoral fellows Athanasios Litsios and Lucie Wolf received the #award for their research on the role of proteins in the cell cycle and colon cancer. #UofT Learn more 👉 uoft.me/2024REA

Our latest paper is out! In collaboration with Anne Carpenter, PhD, we conducted a systematic high-content screen to understand the role of protein mislocalization in diverse human disorders. 1/ cell.com/cell/fulltext/…

A team led by researchers at University of Toronto and Broad Institute mapped the impact of #mutations on protein localization in the cell. They found that one in six disease-causing mutations led to #proteins ending up in the wrong location. Learn more 👉 uoft.me/Mislocalization

Very cool to be featured in 'Humans of RHSE'! RHSE_UofT Donnelly Centre Stephane Angers Read more about my postdoctoral work and beyond here: rhse.temertymedicine.utoronto.ca/news/humans-rh…

A team led by University of Toronto researchers has uncovered new targets that could be key to effectively treating #glioblastoma, a lethal type of brain #cancer. Glioblastoma is challenging to treat due to the resistance of its stem cells to therapy. Learn more 👉 uoft.me/Glioblastoma

🎉 Excited to share our latest work in StemCellReports! This marks the final chapter of my postdoc in the Angers Lab. cell.com/stem-cell-repo… 🧬✨ We show how individual Frizzled receptors regulate Wnt-β-catenin signaling kinetics in hPSCs, influencing mesoderm commitment🧵1/n

🚨Preprint Alert🚨 How does spatial&temporal organization shape Wnt signaling? 🧬🔬 🔍Using #GenomeEngineering, high-content #screening + phosphoproteomics, our study explores how Dvl2 centrosomal phase separation influences #WntSignaling outcomes 📄 doi.org/10.1101/2025.0… 🧵👇

Proud to share our latest manuscript! 🎉 We quantitatively assessed how WNT5a is transported extracellularly at single-molecule and single-particle resolution. 👉 Read the full paper here: doi.org/10.1111/febs.7… 👇🧵