DELE1 oligomerization promotes integrated stress response activation biorxiv.org/cgi/content/sh… #bioRxiv

DELE1 oligomerization promotes integrated stress response activation Excited that we (⁦Xiaoyan Guo⁩ ⁦Giovanni Aviles⁩) could contribute to this work led by Jie Yang ⁦Lander Lab⁩ and see the structure of our friend DELE1 for the first time! biorxiv.org/content/10.110…

Looking for a postdoc to take on cryoEM studies exploring how small molecules impact E3 ligase conformation and substrate binding (a la science.org/doi/10.1126/sc…). Send an email w/ CV to [email protected] please retweet

Mitochondrial stress causes DELE1 to form a large signaling scaffold that activates the integrated stress response. Congrats Jie Yang for initiating this project several years ago, and our amazing collaborators in the @LabWiseman and Kampmann Lab labs! rdcu.be/diKmx

Jie has an amazing knack of identifying incredibly cool biological systems that give rise to unexpected, impactful findings! Anyone lucky enough to join his group at UVA will receive outstanding mentorship while pursuing inspiring, top-tier research! Please Retweet

The first structure of the complete human ClpXP complex. Congrats!