Online now, Jessie and Alina's review article takes a deep dive into how the structures (or lack thereof) of microproteins inform their functions: …iencejournals.onlinelibrary.wiley.com/doi/10.1002/pm…

A cell in metaphase photographed through a microscope. Actin filaments (blue) and myosin II (green) are shown. #CellBiology

A common HLA locus subtype showed protection from Alzheimer's and Parkinson's in an analysis of +176,000 individuals. This HLA subtype was also linked to lower tangles and CSF tau. Pretty interesting! pnas.org/doi/10.1073/pn…

Cool work on a new microprotein encoded by a SCRIB transcript. This microprotein is encoded by a smORF that starts in the 5' UTR and overlaps the main CDS. It comes up in ribo-seq, but this work shows its translation led to a stable protein that binds the WIN site of WDR5.

“The amino acid sequence determines protein abundance through its conformational stability and reduced synthesis cost.” Protein abundance caused by “amino acid arrangement in the sequence and not merely amino acid composition” biorxiv.org/content/10.110… github.com/fburic/protein…

Ribo-Seq is a powerful tool to find translating small open reading frames (smORFs), but it's restricted to smORFs without repetitive regions. Here, my colleague developed an integrative proteogenomics + Ribo-Seq approach to find previously missed smORFs. biorxiv.org/content/10.110…

Very cool paper with relevance to smORFs... Experimental results reveal de novo proteins are more soluble and benefit from the DnaK chaperone system, potentially making them better suited for cellular integration. nature.com/articles/s4155…

Vesicular transport in a bundle of neurons. Made this movie some years ago. Incredible how much material is constantly being moved around in our cells over long distances by tiny (nanometer scale) motor proteins #microscopy, #science, #cells_are_amazing

Want to know what happens when mitochondria get stressed? Check our latest pre-print with Simone Mattei lab on how mitochondria tether hibernating ribosomes as an adaptive response to glucose depletion in yeast! biorxiv.org/content/10.110… #teamtomo #cryoEM #ribosomes #mitochondria

In 21 papers across Science, Science Advances, and Science Translational Medicine, researchers with the #BICCN consortium present an atlas of the human and nonhuman primate brain in unprecedented detail. The results uncover the genetic organization of the human brain. scim.ag/4ro

Here's an excellent STAR protocol for identifying actively translated small open reading frames (smORFs), which is often an initial step to discovering microproteins. Great work from Kevin Cao and @tfmPhD! sciencedirect.com/science/articl…

Want to design genetically encoded inhibitors of your favorite protein? Thrilled to announce our latest work w/ Sebastian, Keating Lab, & Gene-Wei Li Lab, where we leverage massively parallel AlphaFold predictions to discover peptide inhibitors. biorxiv.org/content/10.110… (1/n)

#AlphaMissense, a tool by Google DeepMind, can help researchers learn more about the effects that missense mutations have on disease, and could help identify previously unknown disease-causing genes, according to a Science study. Learn more: scim.ag/5iY

One million years of solitude: the rapid evolution of de novo protein structure and complex biorxiv.org/cgi/content/sh… #biorxiv_evobio

Sparks of function by de novo protein design go.nature.com/48jXz1z

A cancer cell with three nuclei (cyan) videoed through a microscope. Mitochondria (yellow) and the actin cytoskeleton (red) are also shown. #CellBiology

One of my favorite events every year!

Excited to share our #GenoBoost paper out in Nature Communications today, a flexible #PolygenicScore #PGS modelling framework for additive and #NonAdditive dominance effects, incorporating non-zero dominance effects in 40%-67% of variants across multiple traits, including #psoriasis,

There's been amazing coverage of our new paper nature nature.com/articles/s4158… but I wanted to put together a walk-through (and make this accessible as possible). It's a bit long so get a cup of tea! The full version is open access so pls do have a read if you are interested...

Ribosome profiling (Ribo-Seq) has played a key role in discovering functional smORFs and microproteins, but its effectiveness can still be improved. One way to enhance this method is by integrating proteogenomics, which my lab colleague did here: nature.com/articles/s4146…