Huge congrats to UMCDB PhD student Renee Conway Hein and team (Joshua Wu @tristanfrum Alyssa J Miller, PhD and collaborators)! R-SPONDIN2+ mesenchymal cells form the bud tip progenitor niche during human lung development, in Developmental Cell cell.com/developmental-… #organoids

Excited to explore at #ISSCR2022 - come visit our booth Conception at the start-up pavillion to learn more about making eggs from #stemcells (and talk to me)!

How well do “mini-organs” in a dish recapitulate the human tissue? We set out to answer this question for the human eye, a super fascinating organ! I'm excited to share our preprint on bioRxiv. Check out the full story through the link! 🧵biorxiv.org/content/10.110…

Our work on chromosome micro-manipulation in living cells is out in Science Magazine! science.org/doi/10.1126/sc… What if you could put your hand 🫳 inside a nucleus, grab a small portion of a chromosome 👌, and see how it reacts when you pull on it? 🤔 … 🧵 1/n

Our crazy journey on this continues - New Hanna lab Cell paper is out: "Post-Gastrulation Synthetic Embryos Generated Ex Utero Solely from Mouse Naïve ESCs" by the amazing @TaraziShadi Alejandro Aguilera Castrejon @carinejoubran Noa Novershtern & Itay Maza cell.com/cell/fulltext/…

Here comes "spatial-ATAC-seq"!!! A wonderful collaboration between my lab at @YaleSEAS and GonçaloCasteloBranco at Karolinska Institutet #epigenetics #spatialomics #spatialbiology Spatial profiling of chromatin accessibility in mouse and human tissues | Nature nature.com/articles/s4158…

I heaved an audible sigh of contention just now after seeing a beautiful western blot in a paper from 2003. UMAP plots and heatmaps just don't hit the same way. A good reminder that the best technique for your experimental readout might not be the fanciest. #laboratorylife

But also…it’s ok to get really excited about fancy new techniques

Love this. In science, asking early = speed. I am surrounded by people with skills and experience I don’t have. Ask if you don’t understand. Ask how to improve ideas. Ask what experiment, controls and readouts will prove your hypothesis wrong the fastest.

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This is our embryo model no5. Very similar to our model no4 published 2 weeks ago but now derived exclusively from stem cells that we programmed to specific fates. Huge thanks to 3 years of work from amazing PhD student Kasey & collaborators Hernan & Yonatan (not on Twitter)

Well, this field has exploded! So much exciting work published in the last few months

Check out our novel method of generating primordial germ cell like cells efficiently in 2D from primed hPSC #stemcells #embryogenesis #gametogenesis biorxiv.org/content/10.110…

Love this - we are working to put it into practice at with our teams. Downside is now the number of slack channels I have has more than tripled...

Founder-led biotech is not a new phenomenon. Despite a lot of skepticism and pushback (technical) founders have built and led very successful, multi-billion dollar biotech companies before. I wanted to share a few of my favorite founding stories. 🧵

Congrats to Renee Conway Hein and the team at Jason Spence, shedding light on lung developmental biology using single cell transcriptomics and really cool in vitro culture systems!

Lung organoids made the cover! Check out my final publication from my postdoc in Lonnie Shea's lab. Huge shout out to Joe Decker, Renee Conway Hein, and Alyssa J Miller, PhD to bring this to the finish line! liebertpub.com/doi/10.1089/te…

Our paper (with co-first author Yolanda Chang ), on in vitro primordial germ cell (PGC) specification is now online! Very proud of this, it took effort to figure it out. Check it out you're interested in PGCs, amnion, early embryology models cell.com/cell-reports-m…

A new manuscript from the lab led by MSTP student, Ansley Conchola, with @tristanfrum Peggy Hsu MD PhD and others... Regionally distinct progenitor cells in the lower airway give rise to neuroendocrine and multiciliated cells in the developing human lung pnas.org/doi/10.1073/pn…

Can confirm all of this! Timing is also critical when picking what to work on. Are other technologies converging on a near-future 'hot topic'? Did another cool project have a spin-off question that already has promising preliminary data? Do you have 2 years or 10 years?