Cells cope with altered chromosome numbers by enhancing protein breakdown nature.com/articles/d4158…

Thank you AACR for highlighting this important topic. We have a lot of work to do to change the current sex-neutral practice in dealing with almost all cancers of non-reproductive systems even though sex is clearly an important biological and clinical variable in cancer.

New cell-based immunotherapy offers hope for patients with metastatic lung cancer. Congrats to Dr. Kai He Pelotonia Institute for Immuno-Oncology for leading this important study. cancer.osu.edu/news/new-cell-… #Kai He # Immunotherapy via @osuccc_james

NEW content online! Cancer therapy with antibodies dlvr.it/T6rryP

Many thanks to the Ohio State Alumni Association Board of Directors for touring the #PIIO . Special thanks to Dr. Timothy Gauntner (@Zihai Lab) who discussed the important work being done to better understand the molecular basis of sex differences in #immune response to #cancer .

One example of many emerging NK cell-mediated regulatory roles in constraining T cell immunity against cancer. Science Immunology #NK_cell science.org/doi/10.1126/sc…

Congratulation to @beziatv et al. for a tour de force study showing that Flt3L deficiency strongly affects adult hematopoietic progenitors, B cells, monocytes and DC development while macrophages remained intact in humans. cell.com/cell/fulltext/…

Greetings, #PIIO ! We're selling Team Buckeye Raffle Tickets to raise funds for Pelotonia 2024. 100% of proceeds are dedicated to #cancer research at the
The James
. Please DM for more info. Please Retweet! cancer.osu.edu/for-donors-and…

Had a great visit to the Pelotonia Institute for Immuno-Oncology to discuss the power of the gut #microbiome in modulating anti-tumor immunity and response to #immunotherapy in cancer patients.
Schulich WesternU Western University Lawson Health Research Institute

nature.com/articles/s4159…

Immunology is for everyone!
Excited to share 'Exploring new perspectives in immunology' with Ruslan Medzhitov in Cell.

sciencedirect.com/science/articl…

Yes we can!!

Of 35 patients with transfusion-dependent β-thalassemia treated with gene-edited autologous hematopoietic stem and progenitor cells, 32 had hemoglobin levels maintained without red-cell transfusions for at least 12 consecutive months. Full study results: nej.md/3xYXrI1

The moment is here. Didn’t we all dream about this as medical students?

We previously showed that platelets repress T cell function via GARP-mediated activation of latent TGFb (PMID 28763790 and 31915300). The current two studies suggest that PGE2 released by activated platelets can also blunt anti-tumor CD8+ T cells.

Congratulations to Carl June, awarded the Breakthrough in Life Sciences for the development of #CARTcelltherapy , a revolutionary cancer treatment in which a patient’s own T cells are modified to target and kill their cancer cells.

This is a great look at just a few of the important #immunotherapy efforts underway at the The James, where our Pelotonia Institute for Immuno-Oncology team works every day to break new ground in this growing field of #cancer care.

Meet Dr. Mark Rubinstein Pelotonia Institute for Immuno-Oncology, a brilliant mind whose foundational work (PNAS 2006, PMID: 16757567; Blood 2008, PMID: 18689546; Lancet Oncol 2018, PMID: 29628312; JI 2022, PMID: 35228263) led to U.S. FDA approval of ImmunityBio, Inc. #ANKTIVA , a FIC IL-15R agonist for NMIBC.

Nice to be home. City of Columbus Delaware County, Ohio Pelotonia Institute for Immuno-Oncology

Amazing science, great people and a venue with unmatched beauty - it was a total joy and honor to attend the 2024 conference on sexual dimorphism in cancer in @communeLausanne. Thank you GianPaolo, An Buckinx, Susanna Chiocca, Adriana Maggi, Berna Ozdemir.