Excited to share our preprint led by M. Kamineni HST Harvard Medical School student & with Broad Institute senior postdoc (and soon Clinical & Translational Epidemiology Unit - MGH Harvard Medical School investigator) Zhi Yu using an unbiased radiomics assessment of the spleen to uncover new inflammatory insights about coronary

New work on the spleen's role in coronary artery disease, led by the wonderful Meghana Kamineni and Zhi Yu + Pradeep Natarajan's stellar team!

A recent commentary in bioRxiv discussed data analysis for our mtDNA-based lineage tracing technology ReDeeM. We welcome the points raised and are happy to address these concerns. We believe this will foster constructive dialogue (1/n) doi.org/10.1101/2024.0…

Thrilled to share our work on the germline, transcriptomic, and phenotypic correlates of clonal hematopoiesis without known point mutations in NHLBI TOPMed. Work led with Marios Arvanitis (not on Twitter/X) and Alexis Battle medrxiv.org/content/10.110…

#Colchicine prevents accelerated #Atherosclerosis in #TET2-mutant clonal haematopoiesis released at #ESCCongress and just published in #EHJ👉 bit.ly/3T6JYFW EHJ Editor-in-Chief José Javier Fuster Tetsushi Nakao, MD PhD

🔬Un equipo del CNIC liderado por José Javier Fuster y #ValentinFuster descubre un nuevo factor de riesgo cardiovascular, la hematopoyesis clonal, e identifica un fármaco para reducir sus efectos. Los trabajos, publicados #OpenAccess🔓 en Nature Medicine y #EHJ EHJ Editor-in-Chief

Exploring the chicken-or-egg dilemma between clonal hematopoiesis and atherosclerosis. Our latest study, published today in Nature Medicine (nature.com/articles/s4159…), addresses this critical question. Check out the thread below ⬇️

Exciting work by José Javier Fuster + team now out w/ #ESCCongress in Nature Medicine In PESA, CHIP 🩸🧬 at baseline ➡️ de novo athero (incl DNMT3A, whose relevance to athero has been uncertain) ❗️ No association of subclinical athero w/ subsequent CHIP ❗️ nature.com/articles/s4159…

Our study led by Marian Zuriaga Zhi Yu & with José Javier Fuster uses murine & human genetic studies to infer that individuals with TET2 clonal hematopoiesis may derive potent CV risk-reduction with colchicine academic.oup.com/eurheartj/adva… European Society of Cardiology Journals 🟢Colchicine has been proposed

The clonal hematopoiesis #CHIP 🩸🧬 party continues at #ESCCongress 🎉 Now in EHJ Editor-in-Chief #EHJ, collab co-led by Marian Zuriaga Zhi Yu demonstrates that colchicine 🛑 TET2-driven athero in 🐁 w/ concordant findings in observational human data academic.oup.com/eurheartj/adva… 👇

We previously showed RNA of inflammatory genes modifies #CHIP-driven athero risk❤️ Now, with Marian Zuriaga Pradeep Natarajan José Javier Fuster, we took a step closer to clinical practice, showing colchicine (anti-inflammatory drug)🛑TET2-driven athero in 🐭w/ consistent finding in human

Now online simultaneously with #ESCCongress! Colchicine as a promising candidate to prevent atherosclerosis in TET2-mutant clonal hematopoiesis. A great collaboration with Pradeep Natarajan led by Marian Zuriaga and Zhi Yu. bit.ly/3T6JYFW

Two new studies on mutated blood stem cells clones, appearing frequently in our blood with aging (known as CHIP) —strong association with atherosclerosis nature.com/articles/s4159… —benefit of colchicine, an anti-inflammatory agent, vs atherosclerosis in mice and heart attack in

Prevention requires bold & forward-thinking investments. My OpEd on why letting funding lapse for AllofUsResearch would be a step backwards statnews.com/2024/09/03/all… STAT

I am honored and thrilled to take on the role of Division Director for Genetic Medicine VUMC Department of Medicine! As a junior faculty member, I benefited tremendously from mentorship and support from Nancy J Cox. I look forward to paying it forward Vanderbilt Genetics Institute!

Our study led by M Mesbah Uddin & with Christie Ballantyne uses longitudinal blood-based exome sequencing over median 21y to discover & characterize features of clonal dynamics. nature.com/articles/s4146… Nature Communications

Honored to receive the Gill Heart & Vascular Institute Early Career Award! Grateful for this amazing opportunity 🙏 UK_GillHeart

We are pleased to share our latest study entitled "Exome wide association study for blood lipids in 1,158,017 individuals from diverse populations" (1/19) medrxiv.org/content/10.110…

Check out this massive and important work led by super-talented Satoshi Koyama 🌟, advancing our understanding of lipid genetics using a massive (1.2 million) diverse study population : )