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Dear followers! The structure of Streptomyces chromosome finally revealed! ;) Check our and Vicky's Vicky Lioy papers!!! biorxiv.org/content/10.110… biorxiv.org/content/10.110…

Identification of signaling pathways, matrix-digestion enzymes, and motility components controlling Vibrio cholerae biofilm dispersal pnas.org/content/early/…

Very pleased to see that we are ranked 3⃣3⃣ in the world in Biological Sciences by QS QS World University Rankings. Awesome work from #ntusbs staff and students. #ntusbs community should be proud about this impressive rise over the years 🚀

Pleased to share our latest work on c-di-AMP with great collaborators Esteban Marcellin and Zhao-Xun Liang Cyclic di-AMP Oversight of Counter-Ion Osmolyte Pools Impacts Intrinsic Cefuroxime Resistance in Lactococcus lactis mbio.asm.org/content/12/2/e…

A Bacterial Inflammation Sensor Regulates c-di-GMP Signaling, Adhesion, and Biofilm Formation skyw.io/OmGheo

A historic moment in the world of molecular structural research. #AlphaFold structure predictions for 22 species made freely available by @deepmind, access through UniProt and Protein Data Bank. Learn more at insideuniprot.blogspot.com

Pathway Retrofitting Yields Insights into the Biosynthesis of Anthraquinone-Fused Enediynes pubs.acs.org/doi/10.1021/ja… Hoa Tran zj low

Understanding biology, and host/pathogen interactions in particular (including #SARSCoV2) without looking at glycan part of proteins is simply not possible. You do not have to take my word for it, check that latest issue of Nature instead... nature.com/articles/d4158…

A proof of concept for c-di-GMP phosphodiesterase-activating drugs administered in combination with antibiotics as a viable treatment strategy for otherwise recalcitrant infections nature.com/articles/s4152…

What drives organization of RNA, DNA, and proteins in the nucleus? In our new paper out Cell, we show that non-coding RNAs play a central role through a unique RNA-based mechanism. authors.elsevier.com/c/1e132L7PXf05J

#Biosynthesis of Tasikamides via Pathway Coupling & Diazonium-Mediated Hydrazone Formation by Ma Guang-Lei, H. Candra, L. Mei Pang, J. Xiong, Y. Ding, H. Thi Tran, Zhenjie, H. Ye, M. Liu, J. Zheng, M. Fang, Bin Cao, Zhao-Xun Liang in J. Am. Chem. Soc. pubs.acs.org/doi/10.1021/ja…

To our surprise, we found hydrazone can be formed via diazonium-mediated Japp-Klingemann reaction in microbial cells, thanks to the excellent work of Ma Guang-Lei, Hart, Hoa Tran, zj low, Pang LM... and our collaborators Profs Cao Bin and Fang Mingliang

Enaminone formation drives the coupling of biosynthetic pathways to generate cyclic lipopeptides …mistry-europe.onlinelibrary.wiley.com/doi/abs/10.100… Hart

Today we're making RF Diffusion, our guided diffusion model for protein design with potential applications in medicine, vaccines & advanced materials, free to use. The software has proven much faster and more capable than prior protein design tools. bakerlab.org/2023/03/30/rf-…

“resistant #pseudomonas was especially difficult to eradicate” 😱 nytimes.com/2023/04/03/hea…

Happy to share our review of cyclic-di-AMP signalling in lactic acid bacteria as part of the LAB symposium special edition in FEMS Thanks to Huong Pham Esteban Marcellin Zhao-Xun Liang & Yuwei for your contributions and many years of collaboration academic.oup.com/femsre/article…

Bacterial cGAS-like enzymes produce 2',3'-cGAMP to activate an ion channel that restricts phage replication biorxiv.org/cgi/content/sh… #biorxiv_micrbio

Streptomyces sungeiensis SD3 as a Microbial Chassis for the Heterologous Production of Secondary Metabolites | ACS Synthetic Biology pubs.acs.org/doi/10.1021/ac… A useful Streptomyces strain from the Johor Strait zj low Ma Guang-Lei @

Big Thanks to our collaborators Pimchai Chaiyen Ma Guang-Lei Hoa Tran, Profs Li Jian, and Gao YG An Enzymatic Oxidation Cascade Converts δ-Thiolactone Anthracene to Anthraquinone in the Biosynthesis of Anthraquinone-Fused Enediynes | JACS Au pubs.acs.org/doi/abs/10.102…

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