Where RNA Science Meets AI, May 4–8, 2025, Ascona. Invited speakers: Oliver Stegle Fabian Theis Stirling Churchman Eva Maria Novoa BarbaraTreutlein Rahul Satija Dr Elena Rivas @[email protected] @RouskinLab Yoseph Barash gagneurlab, Rhiju Das, Karla Neugebauer, Jernej Ule Registration open,

I'm hiring: 1. PhD-level Research associate to generate perturbation data 2. ML postdoc to build multimodal generative AI for DNA (eg diffusion and LLM) 3. Bioinformatician (any level) to harmonize functional genomics data for training foundation models DM me if interested!

Our mentor Casey Brown, apart from being an extraordinary scientist, was a brilliant teacher who loved everything genetics. In his honor, some of the world's leading experts came together to create the 'Casey Brown Lecture Series' on human genetics 1/ shorturl.at/eCm7S

An #RNA #splicing project 3 yrs in the making finally sees the light of day. Microexons, meet macroglia… cancerous macroglia, meet engineered T cells (at your own peril). Jointly with A Naqvi Hagen Tilgner / @[email protected] Yoseph Barash et al CHOP Research Penn Medicine biorxiv.org/content/10.110…

📣 New post re our recent findings/methods dev for #sQTL #RNA #Splicing #RNA-Seq. We think this will be highly useful/impactful for (s)QTL detection/quantification. Hope to get (constructive 😉) feedback and much usage from the community! 😀 biociphers.wordpress.com/2025/01/20/a-d…

🚀 New Paper Alert! 🚀 𝐑𝟐𝐃𝐓: a comprehensive platform for visualising RNA secondary structure Check it out in Nucleic Acids Res: academic.oup.com/nar/article/53… Here’s why you should give it a try 🧵👇

We are excited to report the discovery of TIGRs, a widely-occurring RNA-guided system found in bacteria and their viruses. TIGRs consist of a peculiar repeat region which is transcribed into RNA and processed into multiple guide RNAs to direct TIGR-associated proteins to their

Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.

Given some recent publications regarding #RNA #Splicing prediction using #DeepLearning we decided to assess some of those claims with surprising findings that have to do more with the target function you chose… biociphers.wordpress.com/2025/04/09/tis…

📣We are happy to announce the release of MAJIQ V3 😊🎉 check out details here #RNA #Splicing #RNASeq biociphers.wordpress.com/2025/06/20/maj…

Join us for our next Kipoi Seminar with Yoseph Barash,University of Pennsylvania Penn Genetics Penn Computer and Information Science Penn IBI Yoseph Barash 👉From identifying UTR regulatory elements to potential RNA therapeutic targets 📅Wed Jul 2,5:30pmCET 🧬kipoi.org/seminar 🦋@kipoizoo.bsky.social

I worry the pendulum has swung too far towards generalists over specialists, sacrificing wisdom for speed. Resulting in either boring consensus or unserious hype. There is such a thing as deep technical craft, but I’m not sure you can understand if you’ve never done it yourself

Our work on "Evaluating the representational power of pre-trained DNA language models for regulatory genomics" led by Amber Tang with help from Nirali Somia & Steven Yu is finally published in Genome Biology! Check it out! genomebiology.biomedcentral.com/articles/10.11…

Have you wondered how incompletely processed and misprocessed RNAs are retained in the nucleus? Check out our new manuscript led by my talented postdoc Lusong Tian! LENG8 mediates RNA nuclear retention and degradation in eukaryotes biorxiv.org/content/10.110…

📣Abstract deadline is *tomorrow* ! The list of speakers from academia & industry, + dates in Sicily ➡️ you should be on your way to submitting your abstract.... #RNA #therapeutics. rnahorizons.com/abstract-submi…

Latest genomic AI models report near-perfect prediction of pathogenic variants (e.g. AUROC>0.97 for Evo2). We ran extensive independent evals and found these figures are true, but very misleading. A breakdown of our new preprint: 🧵

📣 Attention #RNA #Splicing lovers! How is splicing of exons coordinated??🤔 ➡️ Exon Junction Complex (EJC) coordinates inclusion of blocks of neighboring exons!😯 Cool work by Alexandra Bergfort (Karla Neugebaur's lab) - check it out! (we got to help a bit 😊) genesdev.cshlp.org/content/early/…