3 CT scans’ worth of radiation gives cancer-capable cells an advantage in ‘Game of Clones’ battle in healthy tissue. New research in mice helps understand the risks around low doses of radiation. #AnimalStats Cambridge University bit.ly/2YXIyQ4

When the #brain is hijacked by #cancer. It isn't at all pretty as the @nature cover this week 3 reports, summarized well by a natureNV by Andres Barria nature.com/articles/d4158… and Heidi Ledford's @NatureNews nature.com/articles/d4158…

dotdotdot: an automated approach to quantify multiplex single molecule fluorescent in situ hybridization (smFISH) images in complex tissues biorxiv.org/cgi/content/sh… #bioRxiv

THIs. IS. HUGE!!! A15% improvement in pathological complete response with curative intent pembrolizumab plus chemo in Keynote 522 for #TNBC reported at #ESMO2019

Our study on normal and cirrhotic liver is also out in @nature. Fantastic work by Simon Brunner led by @Matt_Hoare20 and Peter Campbell Wellcome Sanger Institute Normal liver parenchyma is composed of small clones, but this changes with damage and regeneration in cirrhosis

Fantastic paper from the Gerstung lab applies histology based deep learning approach and not only identifies cancer type but also the underlying molecular aberrations.

People will take enormous risks to enter Britain econ.st/2Jl8Rdf

Proud to present the final chapter of the PCAWG Evolution and Heterogeneity Working Group after 7 years: detailed pan-cancer characterisation of intra-tumour heterogeneity! #PCAWG cell.com/cell/fulltext/…

These snippets highlight the huge potential of spatial genomics and transcriptomics with BaSISS to study cancer evolution. This will enable us to measure, understand - and hopefully one day prevent - the key steps of malignant progression. 8/9

It's the result of a great research collaboration combining new technology, clinical oncology and data science. Huge thanks to Carina, Milana, Artem Shmatko, Jun, Young Seok Ju, @stefan_seq, Vitalii Kleshchevnikov, PhD, Vasyl, Tong, Omer Ali Bayraktar, @luiza_moore, Sarah, Andrea and Peter. 9/9

Alright, since folks are commenting on the Guardian article calling Bayes Theorem "obscure", here's a story about doctors, Bayes Theorem, log scales, and learning and listening from people even when they don't know the thing you know.

Excited to share our latest work. We present NanoSeq, a new duplex sequencing method with <5 errors per billion sites in single DNA molecules. A leap in our ability to study mutation in any tissue. 1/ nature.com/articles/s4158…

So proud of this new study. We developed naive and memory B and T single-cell expansion protocols and produced lymphocyte and blood stem cell genomes, from healthy individuals aged 0-81. I am still stunned at the biological insights revealed. [1/10] biorxiv.org/content/10.110…

1/ How do our bodies – with their incredible complexity - come from a single fertilised egg? How is it co-ordinated? What tissues come from what? Why (and how) might it go wrong? These are the questions we asked in our study out in @nature this week. doi.org/10.1038/s41586…

What have we learned from analysing 200,000 SARS-CoV-2 genomes from genomic surveillance in England in the last 9 months? These data provide important context for the current situation related to B.1.617.2. Here’s a summary of the preprint. medrxiv.org/content/10.110…

Delighted to have our deep dive into understanding the #tumourmicroenvironment of high-risk chemotherapy resistant breast cancers published in Clinical Cancer Research today!! School of Cancer & Pharmaceutical Sciences The ICR Science and Innovation at Cancer Research UK doi.org/10.1158/1078-0… kcl.ac.uk/news/immune-ta…

From sequencing and evolutionary theory we know that tumours grow as mosaics of clones - but so far we haven’t been able to see them. The labs of Lucy Yates, MatsNilssonLab and Moritz Gerstung created a new method to map the spatial evolution of cancers: nature.com/articles/s4158…

Interested in spatial biology and cancer evolution? New spatial genomics technologies start unraveling how somatic evolution, tissue microanatomy and tumour microenvironments interact. New review with Lucy Yates Artem Lomakin and ✨ zaira seferbekova nature.com/articles/s4157…