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👏 Celebrating Ph.D. trainee Jordyn VanPortfliet! Jordyn is a visiting Ph.D. candidate from TAMU Genetics and Genomics, working in the A. Phillip West at The Jackson Laboratory. She was recently awarded an F31, "Targeting the Nrf2 axis to reduce lung immunopathology in PolG-related mitochondrial disease."

Check out the latest review issue in Human Molecular Genetics focused on all things mitochondria! Great to work with ShuttLab and our trainees to provide an update on mtDNA in innate immunity.

Up-regulation of cholesterol synthesis by lysosomal defects requires a functional mitochondrial respiratory chain jbc.org/article/S0021-…

Just returned from the #EMBOmitochondrialGene meeting. Great talks, posters, & networking. The excursion to Warsaw Old Town and the Gala dinner were especially cool! Thanks to @NCL_mtDNA, Hauke Hillen, Joanna Rorbach, and Roman Szczesny for organizing!

Delighted to share the last study of the lab led by the fantastic postdoc Luis Carlos Tábara Rodríguez out in Cell !!! We show how MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels. MRC MBU Cambridge University authors.elsevier.com/sd/article/S00…

The work of Xiaoxu Li and collaborators defines a simple continuous and composite trait, termed the metabolic health score, that is more accurate in defining metabolic homeostasis and predicting future disease incidence sciencedirect.com/science/articl…

📘 New Review in Human Molecular Genetics, "Mitochondrial DNA release and sensing in innate immune responses" with Jordyn Van Portfliet & A. Phillip West: bit.ly/4bYeZD9 #jaxresearch

Very excited to share our paper outline a new role for on Cytotoxic T-cells in anthracycline cardiotoxicity out today in Nature Cardiovascular Research nature.com/articles/s4416…

Hello everyone, the new season of MITOtalks is ready to roll, and we have some awesome MITOscience waiting.

Why do we itch? Ask your immune system, and Dr. Sokol and colleagues. They provide a simple and elegant answer to this timeless question. Kudos to the authors on this fascinating discovery. nature.com/articles/s4158… Caroline Sokol MDPhD Harvard Medical School

It was awesome hosting Dr. Raquel Sitcheran via the The Jackson Laboratory Cancer Center Visiting Scientist Program. We made significant progress on collaborative projects related to macrophage immunometabolism and non-canonical NF-κB signaling in cancer. Thanks The Jackson Laboratory for your support!

Such a great initiative by the mitochondrial community! Tune in if you want to learn more about mitochondria.

🎉Due to the unwavering hard work, dedication and commitment of faculty and staff, JAX received an overall rating in the Exceptional range on our National Cancer Institute-Designated Cancer Center renewal, the highest possible ranking for a U.S. cancer center. This is the JAX Cancer Center’s best

This is a great article on choosing a lab and mentor-mentee relationships from an outstanding former TAMU Genetics and Genomics PhD student. Great job Kelsi West ! opensciencetraining.org/blog/2024-12-1…

Most PhD students work 10x harder than needed. I see it daily - smart students drowning in manual tasks tools could handle. (This kills your research productivity) 8 use cases where you can cut your workload in half:

Congratulations to Omkar Shinde and Pingwei Li for resolving the cryo-EM structures of free and cGAMP-bound ABCC1. This paper follows on the great work from Dan Stetson revealing ABCC1 as a cGAMP exporter. sciencedirect.com/science/articl…

It's clear that many do not understand what NIH-funded research does to improve health. It's time to revive a study published 10 years ago that provides incredible information about this. link in the comment Every single new drug approved by the FDA from 2010–2016 was built on

A map of mitochondrial biology reveals the energy landscape of the human brain Wonderful and fun collaboration with Michel Thiebaut de S and many others! Anna Monzel Orian Shirihai Ayelet Rosenberg was the courageous one who tackled this project, and Eugene Mosharov was the engine

Excited to alert you to a new Fusion Conference this October in Malta. #IOSCD25 will cover: • Organelle Crosstalk • DNA Damage & Inflammation • Organelles in Innate Immune Signaling • Organelle Communication in Disease & Aging fusion-conferences.com/conference/182… Fusion Conferences