Delightful 😠 I've had enough of big-name scientists leveraging their fame to exploit others. Is science well served by one dude taking 30 postdoc salaries from the funding ecosystem & producing a few high-tier papers/year? Leaving human wreckage in his wake?

#TECPR1 is activated by damage-induced #sphingomyelin exposure to mediate noncanonical #autophagy Alf Håkon Lystad and colleagues Universitetet i Oslo embopress.org/doi/full/10.15…

The roles of ER-derived "omegasomes" and their hallmark protein DFCP1 in autophagosome biogenesis has remained enigmatic. We now provide evidence that DFCP1 is an ATPase that constricts omegasomes which shape autophagosomes in selective autophagy. rdcu.be/dgmP1

Very happy and proud that this story is finally published. We show that DFCP1 is an ATPase which constricts forming autophagosomes Fantastic work from Viola Nähse Centre for Cancer Cell Reprogramming. Many thanks to our great collaborators Terje Johansen , Veijo Salo, IkonenLab nature.com/articles/s4146…

Autophagic membranes expand by protein-mediated lipid transfer. Want to know how? We're very happy to have played a part in this cool story from the Stjepanovic lab. ATG2 really is a mind-blowing structure!

I’m excited to finally share this project from the Melia Lab where we demonstrate that the lipid transport protein ATG2 is active and highly efficient on phospholipid monolayers. (1/3) biorxiv.org/content/10.110…

Macroautophagy prioritizes turnover of ER and Golgi proteins during nutrient stress. Check out our latest work defining this and the discovery of a selective Golgi degradation pathway. Sharan Swarup, Ian Smith, Wade Harper, Harvard Med Cell Bio nature.com/articles/s4158…

Our paper is now online! ATR promotes micronuclei rupture and clearance.

Local membrane source gathering by p62 body drives autophagosome formation nature.com/articles/s4146…

Proud to share our latest work, published in J Cell Science where we investigate the interactome of the core autophagy protein ATG9A, and characterize a new interaction with the lipid transport protein VPS13A. journals.biologists.com/jcs/article/do… #Autophagy #Lipidtransport #Membranetrafficking

Cultured Cells in standard plastics can actually be Hypoxic & lactate-producing It matters how High the medium level is in your dish/well!🤯 The medium as liquid phase creates a steep oxygen gradient...... 33~50 µL per 96-well make your cells happily oxygenated (Have you added