Cd69 mRNA levels distinguish potent and dysfunctional activation among CD69+ CD8 T cells in tumors Science Immunology Max Arja Ray science.org/doi/10.1126/sc…

Proudly presenting Simon’s paper on asymmetric apportioning of old mitochondria biasing intestinal stem cells for the Paneth cell linage through aKG-dependent metabolism Nature Metabolism nature.com/articles/s4225… University of Helsinki HiLIFE_Helsinki Suomen Akatemia | Research Council of Finland MetaStem

Modulating immune cell fate and inflammation through CRISPR-mediated DNA methylation editing science.org/doi/10.1126/sc…

Scientists show that CREPT/RPRD1B, a protein highly expressed in tumors and essential for crypt-base columnar cell maintenance, was required for revival stem cell differentiation during intestinal regeneration. 👉 bit.ly/46fo0bd

Mitochondrial respiration is necessary for CD8+ T cell proliferation and cell fate ⁦Nature Immunology⁩ nature.com/articles/s4159…

Recent evolution of the developing human intestine affects metabolic and barrier functions Science Magazine Gray Camp Jason Spence science.org/doi/10.1126/sc…

🧫 Scientists at Harvard Medical School found that IL-4 suppressed CD8+ T cell acquisition of an epithelial tissue-resident memory T cell phenotype. Check it out! 👉 Nature Immunology | go.nature.com/3UqRxYg

NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity ⁦nature⁩ nature.com/articles/s4158…

During late gestation, unconventional intraepithelial αβ T cells migrate from the gut to the mammary gland to remodel the tissue for lactation and enhance its mucosal barrier state Deepshika Ramanan Nature Immunology nature.com/articles/s4159… nature.com/articles/s4159…

Immunometabolic defect driving T cell inflammaging thereby leading to gut barrier loss. This can be rectified by T cell transfer- science.org/doi/10.1126/sc…

KIR+CD8+ T cells are increased during human pregnancy and may promote maternal tolerance by suppressing fetal-specific T cells Science Translational Medicine science.org/doi/10.1126/sc…

Intravital imaging the formation and resolution of MHC class II-positive T cell activation niches biorxiv.org/content/10.110…

Aging-Associated Microbiota Drives Treg Dysfunction via TNF Signaling biorxiv.org/content/10.110… #biorxiv_immuno

Divergent ontogeny of Tissue Resident Memory and Tissue Resident Exhausted CD8+ T cells underlies distinct functional potential biorxiv.org/content/10.110… #biorxiv_immuno

🧬 When good proteins go rogue… Shortened forms of p53, the “guardian of the genome”, can clump with healthy p53, blocking its cancer-fighting powers. A new study shows how this hijack happens, and why it matters. elifesciences.org/digests/106469…

A parasitic worm suppresses neurons to evade detection. Researchers from Tulane Medicine say isolating the molecules responsible for the suppression could lead to new painkillers for humans. Read more in the latest press release on AAI News: news.aai.org/2025/08/11/par….

✍️ Dr. Andrew Chan and colleagues synthesizes evidence on the relationship of obesity and T2DM with early-onset CRC, focusing on pathophysiological mechanisms and the mediating roles of diet and lifestyle factors. Nature Reviews Endocrinology | go.nature.com/3HwIu5d

Our study on immune cell aging across tissue compartments that was part of the CZI Chan Zuckerberg Initiative networks for the human cell atlas is out! Longterm collaborations with Peter Sims @yoseflab @Teichlab Cambridge University Columbia Medicine nature.com/articles/s4159…

Excited to share our CITE-seq atlas of the aging human immune system across tissues. Great collaboration with Donna Farber, Yosef Lab, Teichlab, Jo Jones Cambridge University and partnership with CZI Science! nature.com/articles/s4159…

News from the T cell trogocytosis front dlvr.it/TMVJCv #immunology