Our paper on collective 3-D forces of tumor spheroids (and tumoroids and organoids) is published doi.org/10.7554/eLife.… eLife - the journal. The video below shows strange pulsating forces that we see only (why??) in primary luminal B breast carcinoma spheroids.

Cancer ball, OVCAR-3 cell line Forms loose aggregates in 3D culture rather than compact spheroids like the OVCAR-8 cell line Two different ovarian cancer cell lines, variances

Bi/ond's technology 𝐞𝐧𝐚𝐛𝐥𝐞𝐬 𝐫𝐞𝐬𝐞𝐚𝐫𝐜𝐡𝐞𝐫𝐬 to study complex 3D tissues, organoids, ex vivo, spheroids, ... in vitro, which can provide more 𝐚𝐜𝐜𝐮𝐫𝐚𝐭𝐞 & 𝐩𝐫𝐞𝐝𝐢𝐜𝐭𝐢𝐯𝐞 𝐫𝐞𝐬𝐮𝐥𝐭𝐬 𝐭𝐡𝐚𝐧 𝐭𝐫𝐚𝐝𝐢𝐭𝐢𝐨𝐧𝐚𝐥 𝐩𝐫𝐞𝐜𝐥𝐢𝐧𝐢𝐜𝐚𝐥 𝐦𝐨𝐝𝐞𝐥𝐬.

Extracellular electrophysiology on clonal human beta-cell spheroids biorxiv.org/cgi/content/sh… #bioRxiv

Want more control over your PSC cell populations for downstream differentiation? 📝 Take note of our new protocol and learn how to prepare single cells for use in intestinal #organoid differentiations: bit.ly/43BeQm4

Blockade of ß-Adrenergic Receptors by Nebivolol Enables Tumor Control Potential for Uveal Melanoma in 3D Tumor Spheroids and 2D Cultures mdpi.com/1422-0067/24/6…

🥼 A research team from Centre for Genomic Regulation (CRG) explores the physical, biochemical, and genomic differences between #BreastCancer cells 🧫 cultured in 2D and as 3D #spheroids. 😎 Check it out in The EMBO Journal! bit.ly/3vAY89T

How to study #islets Spheroid formation enhances physiological function of human clonal beta-cell lines providing surrogates for primary islets in extracellular electrophysiology #diabetes biorxiv.org/content/10.110…

Exciting news from the #BSP2024! Our very own PhD student Aiste Vitkauskaite 🇺🇦 discussed a pioneering in vitro platform using HepG2 spheroids to culture F. hepatica parasites. This cutting-edge technique opens new doors for exploring host-pathogen interactions more closely than ever before!

Pawar et al. show that overactive matriptase activates a PAR-2/PI3K/Akt/MMP9 signaling axis to enhance spheroid dissemination and #metastasis in #OvarianCancer. hubs.la/Q02ry_Mz0 From our #Cancer Cell Biology collection: hubs.la/Q02ry-K20 #AACR2024

🔬 Exciting talk at #AACR2024! 👩‍🔬Alison Taylor, PhD 🧬A genome engineering approach using CRISPR-Cas9 genome editing, computational approaches, and organoid models to understand cancer aneuploidies and potential precision oncology targets for patients. abstractsonline.com/pp8/#!/20272/p…

Molecular & physical differences of #breastcancer cells grown in 2D vs 3D: #spheroids have eg. more compact chromatin & distinct downregulated #genes. Image & research by Julieta Ramirez Cuellar, Roberto Ferrari et al Guillermo Vicent BIST-Barcelona Institute of Science and Technology in The EMBO Journal. On bpod.org.uk/archive/2024/4…

Stop by our joint poster session with Agilent Technologies and Dr. Tony Wood from CST at #AACR24: Quantitative Evaluation of Biomarkers for TGF-β-Induced Epithelial-Mesenchymal Transition in Biochemical, Cellular, and 3D Spheroid Model Systems. 🗓️ Sunday, April 7, 1:30-5 PM 📍 Poster

Are you interested in #lung and #airway #organoids and 3D cell culture models 🧫? Come and join us on the Lung and Airway Organoid Workshop on the 29th of April ImperialOrganoid NIHR Imperial BRC NHLI More info in: imperial.ac.uk/events/175659/…

Big couple of days for the team at #AACR24. Mathew Garnett will be presenting *today* on the development of an organoid biobank for dependency mapping. Ballroom 20CD at 13:25. Also, don't miss Gabriele Picco tomorrow presenting novel WRN helicase inhibitors.

We are demonstrating our COPAS Vision™ large particle flow cytometer in the EMBL Advanced Mobile Laboratory (AML) during its stop in Naples as part of the EMBO Lecture Course: Imaging Marine Organisms Across Scales. Automation of marine organisms, meiofauna, plankton and algae.

Developmental biologists, Gary Ruvkun & Victor Ambros, The Nobel Prize ceremony today. They were honored for their discovery of microRNAs using C elegans. Society for Developmental Biology